EGLN1, EGLN2 and EGLN3 are proline hydroxylase whose main function is the regulation of the HIF factors. They work as oxygen sensors and are the main responsible of HIFα subunits degradation in normoxia. Being their activity strictly oxygen-dependent, when oxygen tension lowers, their control ...
By developing an enzyme-substrate trapping strategy coupled with TAP-TAG or orthogonal GST- purification followed by mass spectrometry, we identify adenylosuccinate lyase (ADSL) as an EglN2 hydroxylase substrate in triple negative breast cancer (TNBC). ADSL expression is higher in TNBC than other ...
Product Name: EGLN2 (Egl Nine Homolog 2, Hypoxia-inducible Factor Prolyl Hydroxylase 1, HIF-prolyl Hydroxylase 1, HIF-PH1, HPH-3, Prolyl Hydroxylase Domain-containing Protein 1, PHD1, Estrogen-induced Tag 6, EIT6, DKFZp434E026) (MaxLight 550) Synonyms: EGLN2 (Egl Nine Homolog 2, Hypox...
中文名称:脯氨酰羟化酶抗体,Anti-PHD1/prolyl hydroxylase 英文名称:Anti-PHD1/prolyl hydroxylase 别名: Egl nine homolog 2; EGLN 2; EGLN2; EIT 6; EIT6; HIF P4H 1; HIF PH1; HIFPH1; HPH 3; HPH3; P4H1; PHD 1; PHD1; EGL nine (C.elegans) homolog 2; EGLN2_HUMAN. ...
全球有 1家供应商EGLN2 (Egl Nine Homolog 2, Hypoxia-inducible Factor Prolyl Hydroxylase 1, HIF-prolyl Hydroxylase 1, HIF-PH1, HPH-3, Prolyl Hydroxylase Domain-containing Protein 1, PHD1, Estrogen-induced Tag 6, EIT6, DKFZp434E026) (MaxLight 550)国内生产厂家 ...
C. Elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by Prolyl Hydroxylation. Cell 107, 43–54 (2001). Article CAS PubMed Google Scholar Lando, D. et al. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-...
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase Cancer Cell, 16 (2009), pp. 413-424 View PDFView articleView in ScopusGoogle Scholar [28] H. Boulahbel, R.V. Duran, E. Gottlieb Prolyl hydroxylases as regulators of cell metabolism Biochem. Soc. Trans., 37 ...
PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer Agnieszka A Rawluszko1*, Katarzyna E Bujnicka1, Karolina Horbacka2, Piotr Krokowicz2 and Paweł P Jagodziński1 Abstract Background: Colorectal cancer (CRC) is one of the most common and comprehensively studied ...
Control of cyclin D1 and breast tumorigenesis by the EglN2 prolyl hydroxylase. 2-Oxoglutarate-dependent dioxygenases, including the EglN prolyl hydroxylases that regulate HIF, can be inhibited with drug-like molecules. EglN2 is estrog... Q Zhang,J Gu,L Li,... - 《Cancer Cell》 被引量: ...
Results from different trails have provided evidence of protective effects of cis- 9,trans-11-conjugated linoleic acid (CLA) on cardiovascular diseases. But the inhibition of prolyl hydroxylase 1 (PHD1) associated with induction of hypoxia inducible fact