Lysosomes as a therapeutic target Srinivasa Reddy Bonam, Fengjuan Wang & Sylviane Muller Nature Reviews Drug Discovery volume 18, pages 923–948 (2019)Cite this article 91k Accesses 478 Citations 65 Altmetric Metrics details Abstract Lysosomes are membrane-bound organelles with roles in process...
Lysosomes serve as the platforms for proper recruitment, assembly, and activation of mammalian target of rapamycin (mTOR) complex 1 (mTORC1), the mediator that coordinates the balance between anabolism and catabolism (Fig.2).37,38When nutrients are abundant, the stimulation of amino acids such as...
Signals from the lysosome: a control centre for cellular clearance and energy metabolism Nat. Rev. Mol. Cell Biol. (2013) J.P. Luzio et al. Lysosomes: fusion and function Nat. Rev. Mol. Cell Biol. (2007) S.R. Bonam et al. Lysosomes as a therapeutic target Nat. Rev. Drug Discov...
Their involvement in such essential cellular functions has renewed clinical interest in targeting the lysosome as a novel way to treat disease, particularly cancer. Acute myeloid leukemia (AML) is an aggressive blood cancer with a low survival probability, particularly in older patients. The genomic ...
Together, these discoveries highlight the lysosome as a regulatory hub for cellular and organismal homeostasis, and an attractive therapeutic target for a broad variety of disease conditions. 展开 DOI: 10.1038/s41580-019-0185-4 年份: 2019
Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) play a crucial role in immunity, as they are responsible for the elimination of both virally infected and tumorigenic cells. The clearance of target cells is dependent on the regulated exocytosis of secretory lysosomes, which can ...
Long known as digestive organelles, lysosomes have now emerged as multifaceted centers responsible for degradation, nutrient sensing, and immunity. Growing evidence also implicates role of lysosome-related mechanisms in pathologic process. In this review
to the main neurodegenerative disease, cell biological observations are now beginning to unravel the intracellular pathways involved in the molecular pathogenesis of neurodegeneration: as a result, it is now appropriate to consider therapeutic manipulation of the lysosomal system as an approach to ...
the organelle. Here, we collectively classify these coordinated pathways as the lysosomal processing and adaptation system (LYPAS). We review evidence that the LYPAS is upregulated by diverse cellular stresses, its adaptability regulates senescence and cell death decisions, and it can form the basis...
ADB demonstrates special lysosomes and mitochondria dual-organelles targeting, bright NIR aggregation-induced emission (AIE) at 736 nm, high singlet oxygen (1O2) quantum yield (0.442), as well as good biocompatibility and photostability. In addition, ADB can act as a two-photon imaging agent...