Lysosomes as a therapeutic target Srinivasa Reddy Bonam, Fengjuan Wang & Sylviane Muller Nature Reviews Drug Discovery volume 18, pages 923–948 (2019)Cite this article 93k Accesses 64 Altmetric Metrics details Abstract Lysosomes are membrane-bound organelles with roles in processes involved in...
Lysosomes are membrane-bound organelles with roles in processes involved in degrading and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes encoding lysosomal proteins cause lysosomal storage disorders, in which enzyme replacement therapy has proved successful. Growing ...
et al. Targeting the mitochondrial protein VDAC1 as a potential therapeutic strategy in ALS. Int. J. Mol. Sci. 23, 9946 (2022). Article CAS PubMed PubMed Central Google Scholar Peng, W., Wong, Y. C. & Krainc, D. Mitochondria-lysosome contacts regulate mitochondrial Ca2+ dynamics via...
Together, these discoveries highlight the lysosome as a regulatory hub for cellular and organismal homeostasis, and an attractive therapeutic target for a broad variety of disease conditions. 展开 DOI: 10.1038/s41580-019-0185-4 年份: 2019
Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) play a crucial role in immunity, as they are responsible for the elimination of both virally infected and tumorigenic cells. The clearance of target cells is dependent on the regulated exocytosis of secretory lysosomes, which can ...
Long known as digestive organelles, lysosomes have now emerged as multifaceted centers responsible for degradation, nutrient sensing, and immunity. Growing evidence also implicates role of lysosome-related mechanisms in pathologic process. In this review
to the main neurodegenerative disease, cell biological observations are now beginning to unravel the intracellular pathways involved in the molecular pathogenesis of neurodegeneration: as a result, it is now appropriate to consider therapeutic manipulation of the lysosomal system as an approach to ...
shown that the TRPML2 channel plays a crucial role in the release of chemokines as well as in the stimulation of macrophage migration [126,127]. NK cell activity is regulated by the dynamic balance between activating and inhibitory signals, which determine whether NK cells kill the target cell...
scientists have made significant contributions to reveal the structural characteristics and drugs of lysosomes and to connect lysosomes with important pathways such as autophagy, endocytosis, mTOR, and cell death, laying a foundation for the later use of lysosomes as therapeutic targets. Christian de Du...
Most importantly, the knockout of LDLR effectively inhibits RSV infection in vivo. These findings elucidate the molecular mechanism of how RSV co-regulates lysosomal cholesterol reprogramming and autophagy and reveal LDLR as a novel target for anti-RSV drug development....