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A dileucine signal situated in the C-terminal tail of the lysosomal membrane protein p40 is responsible for its targeting to lysosomes. 来自 掌桥科研 喜欢 0 阅读量: 50 作者:M Boonen,RRD Castro,G Cuvelier,I Hamer,M Jadot 摘要: Transport of newly synthesised lysosomal membrane proteins from the...
et al. Lysosome-targeting chimaeras for degradation of extracellular proteins. Nature 584, 291–297 (2020). This paper provides the first, to our knowledge, description of the LYTAC system and the first example of its use for the degradation of extracellular proteins. Article CAS PubMed PubMed...
3. Drug discovery by targeting autophagy-related protein–protein interactions 4. General strategies for obtaining protein–protein interaction regulators 5. Perspectives Acknowledgments Author contributions Conflicts of interest ReferencesShow full outline Cited by (9) Figures (7) Show 1 more figure Table...
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We conjugated antibody-based binders targeting cell-surface proteins to a tri-GalNAc motif that engages ASGPR. The resulting LYTACs directed lysosome trafficking of the bound targets and subsequent degradation. Degradation mediated by an EGFR-targeted GalNAc-LYTAC resulted in significant functional effects...
Protein complexes in transport vesicle targeting Wei Guo, ... Peter Novick, in Trends in Cell Biology, 2000 Three new vacuolar protein sorting (VPS) gene products of yeast, Vps52p, Vps53p and Vps54p, were shown recently to form a stable, 300-kDa complex59. This multimeric complex loca...
(UPS), or by the lysosome. Targeting proteins for degradation involves ubiquitination of the protein, a multistep process involving E1 (Ub activating enzymes), E2 (Ub conjugating enzyme) and E3 Ligases, where one or several ubiquitins (Ub) are covalently attached to the target protein. The ...
et al. Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice. J. Cell Biol. 184, 491–500 (2009). Article CAS PubMed PubMed Central Google Scholar Babetto, E. et al. Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency...