Examines the localization and movement of melanosomal proteins through the endosomal pathway of highly pigmented melanocytic cells. MNT-1 cells as a model for melanosome development; Localization of Pmel17 and TRP1 to distinct melanosomal stages; Relationship of premelanosomes, lysosome-related ...
Focuses on a study which indicated that the adenosine phosphate (ADP)-ribosylation factor domain protein 1 (ARD1) contained a particular subcellular localization, which was distinct from those of the ADP ribosylation factor (ARF). In-depth look at the ARF; Details on the ARD1; Methodology used...
Immunoelectron microscopic localization of ubiquitin in hepatoma cells. EMBOJ 1988; 7: 2961-66. 5. Laszlo L, Doherty FJ, Osborn NU, et al. Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts. FEBS Lett 1990; 261: 365-68. 6. Laszlo L, Tuckwell J...
Subcellular protein localization regulates protein function and can be corrupted in cancers1 and neurodegenerative diseases2,3. The rewiring of localization to address disease-driving phenotypes would be an attractive targeted therapeutic approach. Molec
(PTMs) are typically reversible enzymatic reactions that add or remove a functional group, such as a phosphate group. PTMs are often required for properprotein foldingto occur and they can control the activity of a folded protein by changingsubcellular localizationor inducing a switch between ...
The yellow in the perinuclear region of the neurons (A) and astrocytes (C) indicates localization of BODIPY-tocopherol to lysosomes. The yellow in the overlaid images indicates that BODIPY-tocopherol localizes to mitochondria in the astrocytes (D) but not in the neurons. These findings were ...
Subcellular or extracellular localization may influence protein half-life due to the predominant proteolytic mechanisms presented in various compartments. For some proteins, exit from the tissue-of-origin may represent a considerable removal mechanism, which should be taken into account when interpreting ...
Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell linesLAMP1LysosomeBHK-21CHO-K1... K Baba,S Kuwada,A Nakao,... - 《Histochemistry & Cell Biology》 被引量: 0发表: 2020年 Natural Resistance to Infection with Intracellular Pathogens: The Nramp1...
Confocal laser microscopy showed co-localization of LIMP-2 with IgG along the glomerular basement membrane. Serum antibodies against LIMP-2 could not be detected. In conclusion, our data show the value of urinary microvesicles in biomarker discovery and provide evidence for de novo expression of ...
Evidence for Proteasome Involvement in Polyglutamine Disease: Localization to Nuclear Inclusions in SCA3/MJD and Suppression of Polyglutamine Aggregation i... Hofmann K , Falquet L ( 2001 ) A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems ...