Lysosomes as a therapeutic target Srinivasa Reddy Bonam, Fengjuan Wang & Sylviane Muller Nature Reviews Drug Discovery volume 18, pages 923–948 (2019)Cite this article 91k Accesses 478 Citations 65 Altmetric Metrics details Abstract Lysosomes are membrane-bound organelles with roles in process...
Lysosomes as a Target of Anticancer Therapy An interesting approach in the treatment of cancer and the search for ways to overcome the chemoresistance of cancer cells may also be combining ... W Trybus,E Trybus,T Krol - 《International Journal of Molecular Sciences》 被引量: 0发表: 2023年 ...
Lysosomes have become an important target for anticancer therapeutics because lysosomal cell death bypasses the classical caspase-dependent apoptosis pathway, enabling the targeting of apoptosis- and drug-resistant cancers. However, only a few small molecules—mostly repurposed drugs—have been tested so ...
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release
Targeting autophagy in cancer stem cells as an anticancer therapy. Cancer Lett. 2017;393:33–9. Article CAS Google Scholar Sasaki K, Tsuno NH, Sunami E, Tsurita G, Kawai K, Okaji Y, et al. Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC ...
Being originally discovered as cellular recycling bins, lysosomes are today recognized as versatile signaling organelles that control a wide range of cellular functions that are essential not only for the well-being of normal cells but also for malignant
Lysosomes are an important component of the inner membrane system and participate in numerous cell biological processes, such as macromolecular degradation, antigen presentation, intracellular pathogen destruction, plasma membrane repair, exosome release
Lysosomes have distinct functions in autophagy and cell death processes.Lysosome is a promising target for inducing ferroptosis by modulating iron metabolism in cancer cells.Targeting lysosomes via ferritinophagy, TFEB activation, and lysosomal iron overload offers new avenues for cancer treatment.Utilizing...
Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents. Mitochondria-targeted compounds represent a promising approach to target tumors selectively and overcome resistance to current anticancer therapies. In thi... Y Li,CP Tan,...
Lysosomes serve as the platforms for proper recruitment, assembly, and activation of mammalian target of rapamycin (mTOR) complex 1 (mTORC1), the mediator that coordinates the balance between anabolism and catabolism (Fig.2).37,38When nutrients are abundant, the stimulation of amino acids such as...