LYTACs induce selective degradation of extracellular proteins by recruiting them to cellular receptors that mediate delivery to the lysosome. Recent development of GalNAc-LYTACs and MoDE-As targeting the liver-specific ASGPR enables cell-type-restricted lysosomal protein degradation and reveals new LYTAC de...
LYTACs induce selective degradation of extracellular proteins by recruiting them to cellular receptors that mediate delivery to the lysosome. Recent development of GalNAc-LYTACs and MoDE-As targeting the liver-specific ASGPR enables cell-type-restricted lysosomal protein degradation and reveals new LYTAC ...
Families of cell-surface lysosome-targeting receptors (LTRs) have been reported that facilitate the transport of proteins to lysosomes 9 . We proposed that chimeric molecules capable of binding both a cell-surface LTR and an extracellular protein might induce internali-zation and lysosomal degradation...
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J. (2004). Rab11 regulates the recycling and lysosome targeting of beta2-adrenergic receptors. J. Cell Sci. 117 , 3107-3117.Moore,RH,Millman,EE,Alpizar-Foster,E,Dai,W,Knoll,BJ.Rab11 regulates the recycling and lysosome targeting of beta2-adrenergic receptors. Journal of Cell Science . ...
hypothesized that ibuprofen increases the risk of developing severe and fatal COVID-19 as it is known that it can increase the expression of ACE-2 receptors [40]. However, this has not been supported by any clinical study, and cannot be confirmed post hoc given the common practice of not ...
PDGFR trafficking such that receptors are initially internalized but undergo recycling back to the cell membrane instead of targeting to the lysosome (16). ... A Ignatiuk,JP Quickfall,Andrea,... 被引量: 31发表: 0年 Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool...
Unlike many lysosomal enzymes which are translocated into lysosomes through the mediation of the Man-6-P receptors, transport of APase to lysosomes was independent of the Man-6-P receptor system. The transport of APase to lysosomes is dependent on the GY-motif which is located in its ...
Muskelin acts as a regulatory component in the inward-directed transport of GABAA receptors (GABAARs) through myosin VI motors and, furthermore, connects GABAARs directly to the dynein motor complex. Its ability to associate with actin- and microtubule-based motor protein complexes is unique (...
The biotin moiety in TPP-PEG-biotin can be effectively delivered to cancer cells, such as MCF-7 and HepG2, in which biotin receptors are overexpressed. In addition, TPP-PEG-biotin was reported to be localized in the lysosome of MCF-7 cells [12]. The self-assembled nanoparticles (SANs) ...