VPS10P-domain receptors — regulators of neuronal viability and function. Nature Rev. Neurosci. 9, 899–909 (2008). Article CAS Google Scholar Ni, X. & Morales, C. R. The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptor. Traffic 7,...
Rab GTPases regulating receptor trafficking at the late endosome-lysosome membranes. Cell Biochem Funct 30: 515-523, 2012.Ng EL, Gan BQ, Ng F, Tang BL. Rab GTPases regulating receptor trafficking at the late endosome-lysosome membranes. Cell Biochem Funct. 2012; 30:515-523....
They welcome and degrade macromolecules from various membrane-trafficking pathways like autophagic, endocytic, phagocytic, and secretory mostly for cell substrate breaks down. Lysosomal enzymes carry out precise biochemical reactions in breaking the substrates into smaller components which need to be either ...
proteins are synthesized in the ER. Sorting to lysosomes occurs through multiple pathways. 1. Most acid hydrolases are delivered to lysosomes via a mannose 6-phosphate (M6P) dependent ER-to-lysosome trafficking pathway. M6P modified proteins are recognized by M6P receptors (MPRs) in the trans-...
We show that LYTACs can serve as biochemical probes for the study of receptor trafficking and protein degradation, and can mediate the degradation of both secreted and membrane-associated proteins of therapeutic interest.https://doi.org/10.1038/s41586-020-2545-9Received: 1 May 2019Accepted: 22 ...
The trafficking of most lysosomal hydrolases is mediated by a mannose-6-phosphate (M-6-P)-dependent pathway, in which asparagine-linked oligosaccharides on newly synthesized lysosomal enzymes are modified in a two-step process to contain a terminal M-6-P moiety. The initial step in posttranslati...
PDGFR trafficking such that receptors are initially internalized but undergo recycling back to the cell membrane instead of targeting to the lysosome (16). ... A Ignatiuk,JP Quickfall,Andrea,... 被引量: 31发表: 0年 Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool...
Long known as terminal degradation stations, lysosomes have emerged as sophisticated signalling centres that govern cell growth, division and differentiation. Lysosomes interface physically and functionally with other organelles, and the master regulator
an acidic pH to function properly.Note:Endosomes are basically sorting organelles within cells. They control protein and lipid trafficking in the plasma membrane Golgi, the trans-Golgi network (TGN), and vacuoles/lysosomes, among other subcellular compartments of the secretory and endocytic ...
hydrolases; altered plasma-membrane receptor assembly; altered sequestration of growth factors; altered sequestration, recruitment and presentation to signaling receptors of cytokines; abnormal extracellular matrix crosslinks; altered cell attachment and interference with cellular trafficking; and macrophage...