Lee BL, Barton GM. Trafficking of endosomal toll-like receptors. Trends Cell Biol. 2014Lee, B. L., and G. M. Barton. 2014. Trafficking of endosomal Toll-like receptors. Trends Cell Biol. 24: 360-369.Lee BL, Barton GM. Trafficking of endosomal Toll-like receptors. Trends Cell Biol ...
Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide (LPS, endotoxin) of Gram-negative bacteria and sequentially triggers two signaling cascades: the first one involving TIRAP and MyD88 ad...
Toll-like receptors (TLR) are essential components of the innate immune system. Several accessory proteins, such as UNC93B1, are required for transport and activation of nucleic acid sensing Toll-like receptors in endosomes. Here, we show that BAD-LAMP (LAMP5) controls TLR9 trafficking to LAMP...
Despite important progress toward deciphering human hepatitis B virus (HBV) entry into host cells, many aspects of the early steps of the life cycle remain... Alina,Macovei,Catalina,... - 《Journal of Virology》 被引量: 74发表: 2013年 Endosomal trafficking of AMPA receptors in frontal corte...
found that syndecan-syntenin interacted directly with ALIX protein via Leu-Tyr-Pro-X(n)-Leu motif to support the intraluminal budding of endosomal membranes, which is an important step in exosome formation [35]. All of these studies indicate that a set of molecules act as a regulatory network...
Such a strat- egy to reactivate TAMs consists in activating key innate immune receptors such as Toll-like receptors. In this context, the endosomal TLR9 is considered as a potent therapeutic target. It is involved in the recognition of double-stranded DNA rich in unmethylated CpG motifs of ...
TLR9 is an endosomal TLR that also modulates the inflammatory cytokine response to fungal pathogens. In this study, we demonstrate that β-1,3 glucan beads are sufficient to induce dynamic redistribution and accumulation of cleaved TLR9 to phagosomes. Trafficking of TLR9 to A. fumigatus and C. ...
After discovery of ALIX as an accessory factor in the ESCRT (endosomal sorting complex required for transport) system [7–10] and identification of novel ALG-2-interacting proteins in different systems, much attention has been paid in recent years to the role of ALG-2 in ...
Endosomal trafficking inhibitor EGA can control TLR7-mediated IFNa expression by human plasmacytoid dendritic cellsdoi:10.3389/fimmu.2023.1202197DENDRITIC cellsSYSTEMIC lupus erythematosusTOLL-like receptorsINFLUENZA virusesAUTOIMMUNE diseasesPlasmacytoid dendritic cells (pDC) are the major ...
Viral cores composed of σ2, λ2, λ1, μ2, and λ3 escape the endosomal compartment to initiate viral RNA synthesis. Figure prepared using BioRender. Bona fide entry receptors are responsible for virion attachment and internalization. Immunoglobulin superfamily (IgSF) proteins, integrins, and ...