Osch A,Kohlberger P,Gitsch G,et al.Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer. British Journal of Cancer . 1996Alosch,P Kohlberger, Ggitsch,et al.Lysosomal protease cathepsinD is a prognostic marker in endometrial cancer[J].BrjcANCER, 1996, 73(12):1525-...
prognostic markerproteaseCathepsin D is an acidic lysosomal protease present in all cells. In estrogen receptor positive and negative breast cancer cell lines... H Rochefort,F Capony,M Garcia - 《Cancer Metastasis Rev》 被引量: 248发表: 1990年 A prospective study of the prognostic value of ca...
Cathepsin D (CD) is the principal lysosomal aspartate protease and a main endopeptidase responsible for the degradation of long-lived proteins [9,10], including α-syn[11]. CD is expressed widely in the brain, including the cortex, hippocampus, striatum, and dopaminergic (DA) neurons of the ...
The immunohistochemical localization of cathepsin D (CD) was demonstrated for the first time in 54 schwannomas (32 intra- and 22 extracranial; 47 benign an
The immunohistochemical localization of cathepsin D (CD) was demonstrated for the first time in 54 schwannomas (32 intra- and 22 extracranial; 47 benign and 7 malignant) and 5 normal nerve fibers. Granular or vesicular CD-reactive structures were observed in all normal Schwann cells. All tumors...
[16]. For instance, mutations of theGBA1gene encoding the lysosomal hydrolase beta-glucocerebrosidase (GCase) not only cause the LSD Gaucher disease but are also one of the highest genetic risk factors for developing PD [17,18]. The loss-of-function of the lysosomal protease cathepsin D (...
The 52K cathepsin-D-like protease is the first example of a lysosomal protease induced by estrogens in cancer cells. Results obtained using different approaches suggest that two cysteinyl cathepsins are also related to cell transformation and invasiveness. It has been proposed that cathepsin-B is ...
1d). However, the presence of recombinant PGRN greatly facilitates PSAP binding to sortilin-expressing COS-7 cells and subsequent lysosomal targeting as shown by colocalization with the lysosomal protease cathepsin D (Fig. 1d). Furthermore, endocytosed PSAP is processed into intermediates and saposin...
Purification and characterization of a lysosomal aspartic protease with cathepsin D activity from mosquito. Insect Biochem. 21:165-175.Cho, W.; Dhadialla, T.S.; Raikhel, A.S. Purification and characterization of a lysosomal aspartic protease with cathepsin D activity from the mosquito. Insect ...
PGRN deficiency has been shown to impair lysosomal function, and the mature form of the lysosomal protease cathepsin D is overexpressed in R493X−/− KI neurons. Increasing PGRN through G418-mediated PTC readthrough normalized this abnormal lysosomal phenotype in R493X−/− KI neuronal ...