2023年7月27日,上海交通大学Florent Ginhoux及刘兆远共同通讯在Immunity在线发表题为“Dendritic cell type 3 arises from Ly6C+monocyte-dendritic cell progenitors”的研究论文,该研究使用LEGENDScreen分析DC与单核细胞谱系,发现FLT3和CD45RB...
Depletion of KCs by clodronate liposomes enhanced Ly6C+ monocyte recruitment and accelerated HBV clearance in six﹚eek﹐ld mice. Conclusions.Ly6C+ monocytes and KCs may, respectively, represent the resistance and tolerance arms of host defenses. These two cell types play an essential role in ...
The central roles of STAT1 in the genome profile of iMOs lead us to investigate them in STAT1KO mice. Previously we found that STAT1 KO mice were highly resistant to VL in a T cell independent fashion4. Some studies have shown that IFNs could be important for monocyte differentiation in an...
ObjectiveTo investigate the role and mechanism of Ly6C high monocyte in mice with ventilator-induced lung injury (VILI). MethodsForty-eight healthy male SPF C57BL/6 mice were divided into spontaneous breathing group ( n = 8), normal tidal volume (VT) group (VT was 8 mL/kg, n = 8),...
Although other APCs such as splenic CD169+ macrophages, Irf4+CD11b+ DCs or adoptively transferred ex vivo monocyte- derived DCs have been shown to cross-present; the Monocyte efferocytosis and cross-presentation SR Larson et al 1001 cross-presentation for these APCs was demonstrated using either...
Significant increases in the monocyte levels were observed in both the mouse brains and the peripheral blood of patients after SAH. Ly6C-high monocytes originated in the bone marrow, and the skull bone marrow contribute a higher proportion of these monocytes than neutrophils. The mRNA level of ...
Dietary Fiber Confers Protection against Flu by Shaping Ly6c-Patrolling Monocyte Hematopoiesis andCD8+T Cell Metabolism 期刊名称:Immunity时间:2019年 影响因子:21.522 一、背景 膳食纤维及其发酵产物,特别是短链脂肪酸(SCFAs),可以通过抑制免疫反应预防慢性炎症性疾病。膳食纤维对宿主免疫反应的影响不仅局限于胃肠道,...
When Ly6C monocyte-depleted peripheral blood total nucleated cells were adoptively transferred into CCl-treated mice, we found no EGFPCD45 cells in the liver.ConclusionsThese results suggest that Ly6C monocytes can become HpSCs in the injured liver. 展开 ...
In addition to the macrophage fate, Ly6Chi monocytes have been shown to give rise to a distinct population of TNF and iNOS-producing inflammatory monocyte-derived DCs, as well as cells that share other functional features of classical DCs, although functional contributions of these cells remain ...
Alternatively activated macrophages (AAM) that accumulate during chronic T helper 2 inflammatory conditions may arise through proliferation of resident macrophages or recruitment of monocyte-derived cells. Liver granulomas that form around eggs of the helminth parasite Schistosoma mansoni require AAM to limi...