膳食纤维通过改善Ly6c-巡视单核细胞造血功能和CD8+T细胞代谢来预防流感 Dietary Fiber Confers Protection against Flu by Shaping Ly6c-Patrolling Monocyte Hematopoiesis andCD8+T Cell Metabolism 期刊名称:Immunity时间:2019年影响因子:21.522 一、背景 膳食纤维及其发酵产物,特别是短链脂肪酸(SCFAs),可以通过抑制免疫反应...
14. During murine VL, monocytes are recruited into the liver resulting in the formation of granulomas during early and chronic phase of the infection. However, what is not known is the kinetics of such monocyte recruitment, and whether the infiltrate consists of Ly6Chii...
The aim of this study is to elucidate the roles of C/EBPβ in monopoiesis.First, we measured C/EBPβ mRNA expression in purified hematopoietic stem cells, myeloid progenitors and monocyte subsets, and found that monocytes, especially Ly6C– monocytes, expressed C/EBPβ mRNA at extremely higher...
Discrete expression of CX3CR1-GFP in Cx3cr1gfp animals led to the identification of two monocyte subsets in mice: CX3CR1intLy6Chi and CX3CR1hiLy6Clo cells (Geissmann et al., 2003; Palframan et al., 2001). CX3CR1hiLy6Clo“patrolling” monocytes—the correlate of human CD14dimCD16+...
which indicated that the defect occurred during later stages of monocyte development. The defect was cell intrinsic, as wild-type mice that received bone marrow fromNr4a1−/−mice developed fewer patrolling monocytes than did recipients of wild-type bone marrow. The Ly6C−monocytes remaining in...
Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6Chigh and patrolling Ly6Clow monocytes. Alarmins S100A8/A9 locally releas
Alternatively activated macrophages (AAM) that accumulate during chronic T helper 2 inflammatory conditions may arise through proliferation of resident macrophages or recruitment of monocyte-derived cells. Liver granulomas that form around eggs of the helminth parasite Schistosoma mansoni require AAM to limi...
In mice, two functionally distinct monocyte populations are described: (i) pro-inflammatory Ly6C high monocytes; and (ii) patrolling Ly6C low monocytes. Objectives The objective of our study is to investigate the role of S100A8/A9 in the recruitment of the different monocyte populations during ...
Here, we examine whether NEC development is associated with alteration of monocyte phenotypes in the lamina propria (LP) of neonatal intestines, and if so, whether NF-κB activation mediates the effect. To do so, litters containing a mixture of LysM-CreIKKβ(mice lacking IKKβ, the upstream ...
CX3CR1 has also been shown to be involved in the patrolling activity of Ly6Clow-Mo.1,25,26 So far, the CX3CR1 expression on the 2 mouse monocyte subsets has been evaluated based on the EGFP expression in the knock-in Cx3cr1gfp/+. We compared on Ly6Chigh-Mo and Ly6Clow-Mo the ...