To the editor In light of the valuable contribution that Cuomo et al 1 have made to the prevention and management of radiation-induced heart disease, we would like to raise an additional point regarding radiotherapy-induced lung fibrosis (RILF)....
Dosing techniques have been refined to the point that radiation therapy is usually safe and well tolerated. Unfortunately, damaging effects to normal lung inside the radiation field are unavoidable, leading to the clinical syndromes "radiation pneumonitis" and "radiation fibrosis." Onset of disease ...
Radiation-induced changes in lung tissue and development of fibrosis determined by quantitative morphometric methods 来自 掌桥科研 喜欢 0 阅读量: 23 作者:R Kraus,F Steinberg,B Rehn,J Bruch,C Streffer 摘要: This study presents results of morphometric investigations of mouse lungs after single ...
However, despite detailed work on collagen metabolism, the pathogenesis of radiation fibrosis remains unknown. The data on radiation-induced pulmonary cancer, both in man and experimental animals from both external and internal irradiation following the inhalation of both soluble and insoluble alpha and ...
From a teleological perspective, scar formation can be considered a life-preserving response to injury.1 In modern times, however, the fibrotic response has become the disease, with up to 45% of deaths in the industrialized world attributable to diseases characterized by fibrosis.2 The underlying ...
Radiotherapy Induced Lung Injury (RILI) encompasses two phases: an early phase known as Radiation Pneumonitis (RP), characterized by acute lung tissue inflammation as a result of exposure to radiation; and a late phase called Radiation Fibrosis (RF), a clinical syndrome that results from chronic ...
Furthermore, we found a strong correlation between in-vivo functional data and the extent of fibrosis evaluated ex-vivo by high-resolution synchrotron radiation based microCT imaging as well as by classical histology, which also showed a decrease in fibrosis following Nintedanib intervention. This ...
The integrin alpha-v-beta-6-Knockout mouse is protected from Radiation- Induced Lung Fibrosis:implications for the clinic. Munger J,Hadjiangelis N,Emmanuel B,Devitt M,Formenti SC. International Journal of Radiation Oncology Biology Physics . 2004...
Martin M, Remy J, Daburon F (1986) In vitro growth potential of fibroblasts isolated from pigs with radiation- induced fibrosis. Int J Radiat Biol 49: 821–828 CAS Google Scholar Martinet Y, Rom WN, Grotendorst GR, Martin GR, Crystal RG (1987) Exaggerated spontaneous release of platelet...
Experiments show that the kit provided by the invention can detect whether the mouse suffers from radiation-induced lung fibrosis or not by detecting the number of fibrocytes and contents of CCL2/MCP-1 and CCL3/MIP-1alpha. The detection method is simple, and the kit can be used for ...