fibrosissenescencemicroRNAPurpose Progressive, irreversible radiation-induced pulmonary fibrosis (RIPF) is a clinically significant intermediate- to a late-occurring side effect of radiotherapy. Known mechanisms of RIPF include oxidative stress-induced activation of TGF-尾 with activation of SMAD signaling,...
Radiation therapy is critical for the control of many tumors and lung is an important dose-limiting organ that impacts radiation dose prescribed to avoid irreversible pulmonary fibrosis in cancer survivors. Idiopathic pulmonary fibrosis (IPF) is a chroni
Pulmonary fibrosis (PF) threatens millions of people worldwide with its irreversible progression. Although the underlying pathogenesis of PF is not fully understood, there is evidence to suggest that the disease can be blocked at various stages. Inhalation therapy has been applied for lung diseases s...
A Subset of Breg Cells, B10, Contributes to the Development of Radiation-Induced Pulmonary Fibrosis ? 2023 Elsevier Inc.Purpose: Radiation-induced pulmonary fibrosis (RIPF) is a serious side effect of radiation therapy, but the underlying mechanisms are unknown. B10 cells, as negative B regulatory...
Therefore, CBD exhibited the potential therapy for silicosis through inhibiting the silica-induced pulmonary inflammation and fibrosis via the NLRP3/TGF-β1/Smad2/3 signaling pathway.” https://pubmed.ncbi.nlm.nih.gov/39244899/ “CBD ameliorates silica-induced pulmonary inflammation and fibrosis.” ...
Interstitial lung diseases (ILDs) are characterized as infiltrated interstitial inflammatory cells, cellular proliferation, fibrosis within the alveolar wall [136], in which interstitial fibrosis is the predominant phenotype [137]. There are a variety of causes to induce pulmonary fibrosis, such as diff...
Gadolinium-based contrast agents (gadopentetate dimeglumine [Magnevist], gadobenate dimeglumine [MultiHance], gadodiamide [Omniscan], gadoversetamide [OptiMARK], gadoteridol [ProHance]) have been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy (NFD)....
Clinical course and prediction of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2011;183:431–40. Article PubMed Google Scholar Maher TM, Strek ME. Antifibrotic therapy for idiopathic pulmonary fibrosis: time to treat. Respir Res. 2019;20:205. Article PubMed PubMed ...
Stem cell research on pulmonary fibrosis is looking into their potential to treat lung damage, and results indicate their ability to target damaged lung tissue. For example, in 2013, results werepublishedfrom the first international clinical trial on cell therapy for ILF, conducted in Greece. Patie...
et al. Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy. Ann. Intern. Med. 134, 136–151 (2001). This is a seminal position paper that challenged the long-prevailing hypothesis that chronic inflammation has an essential role in ...