There are many of those, such as dopamine, epinephrine and norepinephrine, glutamate, and GABA. Hormones are also released, such as cortisol, oxytocin, prolactin, and vasopressin. There are many types of serotonin receptors, also called 5-HT receptors. Serotonin does not move itself around. It...
DAMPs—danger-associated molecular patterns; GABA—gamma-aminobutyric acid; GPR—G protein-coupled receptor; IL—interleukin; MS—metabolic syndrome; LBP—LPS-binding protein; LPS—lipopolysaccharides; NLRP3—NLR family pyrin domain-containing 3; PAMPs—pathogen-associated molecular patterns; SCFA—short-...
Zebrafish are used as experimental animals in labs all around the world. To ensure that the health of zebrafish is maintained at the highest level, it is important to know the optimal housing conditions of the animals, including the housing density. Guidelines for housing densities of zebrafish ...
Localized low-dose radiotherapy (LLDR) is a targeted form of radiation treatment involving the administration of low doses of ionizing radiation to specific regions of the body, as opposed to the whole-body approach employed in systemic low-dose radiotherapy. ...
Since astrocytes express ApoE, which is critical for Aβ clearance35, we first measured ApoE levels using immunohistochemistry (IHC) and enzyme-linked immunosorbent assay (ELISA) in response to MEE in presymptomatic APP/PS1 mice. To confirm the intracerebral distribution of ApoE, brain tissues were...
Slices were supple- mented with bicuculline (20 μM) to block GABAergic neurotransmission. Neurons in the MVN were visualized with differential interference contrast optics under infrared illumination. Neurons were patched in whole-cell, current-clamp mode using an Axon clamp 700B amplifier. ...
In addition, preliminary evidence14 suggests that testosterone has short- and long-term γ-aminobutyric acid (GABA)-ergic properties, and these actions may further contribute to the modulation of mood in men. Pope et al15 found that 8 of 50 men aged 20 to 50 years treated with high doses...
Objective To identify any associations between depressive symptoms and incident CVD and all-cause mortality in countries at different levels of economic development and in urban and rural areas. Design, Setting, and Participants This multicenter, population-based cohort study was conducted between January...
Allo is a metabolite of thehormone progesterone, one of the two major female hormones (the other being estrogen). Allo binds to receptors for the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. These receptors are also the targets of anti-anxiety drugs such as benzodiazepines. Allo...
Adverse genetic and environmental impacts during early development, such as glucocorticoid hyper-exposure, can lead to changes in the foetal brain, linked to mental illnesses developed in later life. Dysfunction in the GABAergic inhibitory system is associated with depressive disorders....