Slow IPSC kinetics, low levels of alpha1 subunit expression and paired-pulse depression are distinct properties of neonatal inhibitory GABAergic synaptic connections in the mouse superior colliculus. Eur J Neurosci 13, 2088-2098.Juttner, R., Meier, J., and Grantyn, R. (2001). Slow IPSC ...
Studies using proton magnetic resonance spectroscopy (1H-MRS) indicate that unmedicated, acutely depressed patients have decreased levels of gamma-aminobutyric acid (GABA) in the occipital cortex. The aim of this study was to use 1H-MRS to determine if changes in occipital and frontal cortical GAB...
ObjectiveTo compare the mRNA and protein expression levels of γ-aminobutyric acid receptor B2 (GABABR2) in brain regions of male rats with high level aggressive behaviors and low level aggressive behaviors respectively, and provide clues for exploring mechanism of GABA in aggressive behaviors.MethodsW...
Allo is a metabolite of thehormone progesterone, one of the two major female hormones (the other being estrogen). Allo binds to receptors for the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. These receptors are also the targets of anti-anxiety drugs such as benzodiazepines. Allo...
It is possible that activation of inhibitory local GABAergic interneurons, which are known to be prevalent in the DRVL region [9;33] contributed to the low levels of c-Fos expression within DR serotonergic neurons in the present study. It has recently been reported that...
H Nuwagaba-Biribonwoha,A Jakubowski,V Mugisha,P Basinga,A Asiimwe,D Nash,B Elul 摘要: Background We report levels and determinants of attrition in Rwanda, one of the few African countries with universal ART access. Methods We analyzed data abstracted from health facility records of a ...
Low and high seizure frequency TLE are predicted by the respective upregulation and downregulation of specific leukocyte genes involved in canonical pathways of neuroinflammation, oxidative stress and lipid peroxidation, GABA (γ-aminobutyric acid) inhibition, and AMPA and NMDA receptor signaling. Further...
Molecular function analysis showed that GABA receptor binding, peptidase activator, Protease binding are the involved function in low-grade serous ovarian cancer. GABA receptor binding in human cancers may play a critical role in low-grade serous ovarian cancer. ...
We discuss carefully that this double dissociation implicates increased tonic inhibition through activation of extrasynaptic α4-GABAARs by EtOH as the most likely mechanism for the enhancement of LTD-like plasticity. Findings may stimulate further cellular research on the role of tonic inhibition in ...
Since astrocytes express ApoE, which is critical for Aβ clearance35, we first measured ApoE levels using immunohistochemistry (IHC) and enzyme-linked immunosorbent assay (ELISA) in response to MEE in presymptomatic APP/PS1 mice. To confirm the intracerebral distribution of ApoE, brain tissues were...