神经元振荡 (30 —— 100 Hz),当同步整个神经元人口的高伽马频率范围是脑电图的生产性的认知和行为反应 ; 与关联其功能障碍被认为是相关的认知障碍的研究。这些伽玛振荡反映同步的发射的任务有关的神经元人口和由此产生的 γ-氨基丁酸 (GABA) 的快速节奏性抑制作用-包含到皮层锥体神经元抑制 interneurons。
ObjectiveTo compare the mRNA and protein expression levels of γ-aminobutyric acid receptor B2 (GABABR2) in brain regions of male rats with high level aggressive behaviors and low level aggressive behaviors respectively, and provide clues for exploring mechanism of GABA in aggressive behaviors.MethodsW...
Other interesting pathways involve dopaminergic synapse, axon guidance, and GABAergic synapse signaling (Fig. 2B). Figure 2 Differential methylation between normal fallopian tube controls and primary high-grade serous ovarian cancer. (A) Heat map clustering of methylation probes interrogating known genes...
Obesity, associated with the intake of a high-fat diet (HFD), and anxiety are common among those living in modern urban societies. Recent studies suggest a role of microbiome-gut-brain axis signaling, including a role for brain serotonergic systems in the relationship between HFD and anxiety. ...
Ethanol, not detectably metabolized in brain, significantly reduces brain metabolism, probably via action at specific GABA(A) receptors and has measureable metabolic effects at very low concentrations. J Neurochem. 2013;129(2):304–14. https://doi.org/10.1111/jnc.12634. Chang YK, Labban JD, ...
Duration and intensity of lordosis is mediated by actions of the progesterone (P) metabolite, 3α-hydroxy5α-pregnan-20-one (3α,5α-THP) at GABAα receptors in the midbrain ventral tegmental area. Because rats selectively bred for infantile vocalizations may differ in endogenous 3α,5α-...
However, existing single-cell methylomic technologies are based on use of tubes or well plates and these platforms are not easily scalable for handling a large number of single cells. Here we demonstrate a droplet-based microfluidic technology, Drop-BS, to construct single-cell bisulfite sequencing...
Many previous in vivo 1H magnetic resonance spectroscopy (MRS) studies have shown that patients with major depressive disorder (MDD) are associated with perturbations of cerebral metabolism of neurotransmitters glutamate (Glu) and γ-aminobutyric acid (GABA). In this study, we investigated the ...
To our knowledge, this study is the first to measure the developmental refinement of tuning in V1 layer II/III GABAergic neuron populations. In agreement with others, we find that adult inhibitory neurons are less selective to stimulus orientation than excitatory neurons50,92,93. Our analysis di...
For the nervous system alone, available activity indicators have gone beyond calcium and already extended to other intracellular and extracellular neurotransmitters, including dopamine50,51, GABA (γ-aminobutyric acid)52, glutamate53,54, acetylcholine26,55 and so on. Similar to calcium imaging, shot ...