This article, published in the journal Ultrasound in Obstetrics & Gynecology, examines the association between low fetal fraction (FF) of cell-free DNA (cfDNA) and obstetric complications. The study analyzed data from 3048 pregnant women who underwent cfDNA screening for chromosomal defects at t...
QUILT2 can impute using cfDNA NIPT. To impute using cfDNA NIPT, you need to setmethod=niptand specify a path tofflist, which is a textfile, with one entry per line, with a one to one correspondence tobamlist, with the fetal fraction of that sample (i.e. the first row of fflist ...
During enrollment, the cfDNA laboratory protocol was modified once15; the results from both periods are combined for analysis (original algorithm). Independent of the study, the laboratory developed an updated algorithm optimized to improve the no-call rate at a low fetal fraction using a deep ...
Fetal fraction in singleton pregnancies after PGT-A tested embryos is not different from pregnancies with untested embryos. Positive predictive value for an abnormal prenatal-cfDNA-screening result after euploid embryo transfer was reassuringly low (7.7%). PGT-A reliably selects against aneuploidy ...
Cell-Free DNA (cfDNA) is a non-invasive perinatal test (NIPT) used to assess fetal anomalies. The ability to detect fetal chromosomal aneuploidies is directly related to a sample's fetal to total DNA fraction, known as the fetal fraction (FF). The minimum FF is considered 4%, and the ...
To assess the association between low fetal fraction (FF) in prenatal cell-free DNA (cfDNA) testing and adverse pregnancy outcomes.#We conducted a retrospective cohort study of participants of the TRIDENT-2 study (Dutch nationwide government-supported study offering cfDNA screening for fetal ...
Objective To perform a systematic review and meta‐analysis of the available literature on low fetal fraction (LFF) in cell‐free DNA (cfDNA) screening and the risk of fetal chromosomal aberrations. Method We searched articles published between January 2010 and May 2021 in PubMed and EMBASE ...
Participants underwent cell-free DNA (cfDNA) sequencing at 11-13weeks' gestation. Multivariable logistic regressions were performed with the risk of APOs based on various predictor variables. Results:A total of 8457 women were included in the analysis of which 1563 (18.48%) women developed one or...
Low fetal faction was not associated with preterm delivery, low Apgar scores, or small for gestational age.Low fetal fraction of cfDNA among asymptomatic women may serve as a predictor of subsequent placental dysfunction and hypertensive disease....
Obstetrical & Gynecological SurveyBurns W, Koelper N, Barberio A, Deagostino-Kelly M, Mennuti M, Sammel MD, et al. The association between anticoagulation therapy, maternal characteristics, and a failed cfDNA test due to a low fetal fraction. Prenat Diagn. 2017;37(11):1125-9....