SLC26A4-AS1目的 探讨lncRNA SLC26A4-AS1在人垂体瘤中的表达情况,并分析其与垂体瘤侵袭性的关系.方法 收集经病理确诊的16例非侵袭性垂体瘤和25例侵袭性垂体瘤,利用实时荧光定量聚合酶链反应技术检测SLC26A4-AS1在人垂体瘤中的表达,并进一步分析SLC26A4-AS1与垂体瘤临床参数的相关性.结果 与非侵袭性垂体瘤相比,...
作者假设甲状腺癌中的SLC26A4-AS1是通过RBP机制来行使作用的,为此进行了SLC26A4-AS1亚细胞定位分析。随后,利用RNA pull down结合蛋白质谱以及RNA-IP实验确定蛋白质DDX5与SLC26A4-AS1密切结合。敲减/过表达SLC26A4-AS1,DDX5蛋白水平出现相应的升高/降低。 利用蛋白酶体抑制剂MG132及蛋白合成抑制剂CHX处理,确定SLC2...
作者假设甲状腺癌中的SLC26A4-AS1是通过RBP机制来行使作用的,为此进行了SLC26A4-AS1亚细胞定位分析。随后,利用RNA pull down结合蛋白质谱以及RNA-IP实验确定蛋白质DDX5与SLC26A4-AS1密切结合。敲减/过表达SLC26A4-AS1,DDX5蛋白水平出现相应的升高/降低。 利用蛋白酶体抑制剂MG132及蛋白合成抑制剂CHX处理,确定SLC2...
因此,本研究进一步分析鉴定出了6种增强子发生组蛋白差异修饰的lncRNA(LINC00393,KB-1836B5.1,CASC11, RP1-140K8.5, AC005162.1, and AC020916.2)和三种在增强子或启动子上具有DNA甲基化水平差异的lncRNA(CTC-303L1.2, RP11-738B7.1, and SLC26A4-AS1),这些lncRNA可作为 Basal型乳腺癌的预后生物标志物;而甲基...
LncRNA SLC26A4-AS1 markedly inhibited migration, invasion, and metastasis capability of cancer cells in vitro and in vivo. Intriguingly, SLC26A4-AS1 could simultaneously interact with DDX5 and the E3 ligase TRIM25, which promoting DDX5 degradation through the ubiquitin-proteasome pathway. In ...
SLC26A4-AS1在泌乳素瘤,生长激素瘤和促肾上腺皮质激素瘤中表达无明显差异.与SLC26A4-AS1高表达组相比,SLC26A4-AS1低表达组中肿瘤体积≥3 cm^(3)的比例明显增加,侵袭性垂体瘤的比例明显增加,差异具有统计学意义(P<0.05).结论 SLC26A4-AS1在侵袭...
LncRNA SLC26A4-AS1 markedly inhibited migration, invasion, and metastasis capability of cancer cells in vitro and in vivo. Intriguingly, SLC26A4-AS1 could simultaneously interact with DDX5 and the E3 ligase TRIM25, which promoting DDX5 degradation through the ubiquitin-proteasome pathway. In ...
However, no significant difference was observed in the plasma levels of THRIL, LincRNA-Cox2, LincRNA-p21, HULC, SLC26A4-AS1 and APOA1-AS between patients with CAD and controls (Fig. 1C–H). We further divided CAD patients into three subgroups, including stable angina pectoris (SAP), ...
SLC26A4-AS1 promotes AngII-induced cardiac hypertrophy via upregulating SLC26A4 or sponging miR-301a-3p/miR-301b-3p.CONCLUSION\nSLC26A4-AS1 aggravates ... X Han,C Li,Q Ji,... - 《Arquivos Brasileiros De Cardiologia》 被引量: 0发表: 2023年 Cellular Retinoic Acid Binding Protein 2 (CR...
在两个数据集中识别了11个重叠的DelncRNA,包括RP11-366L20.2、 HOXB-AS1、RP4-792G4.2、RP11-93B14.5、HOTAIRM1、AC002454.1、CRNDE、RP11-834C11.5、HOXA-AS2、AGAP2-AS1和CTD-3049M7.1,并用维恩图表示(图1C)。在CGGA...