LncRNA SLC16A1-AS1miR-182PDCD4乳腺癌是全球女性最常见的恶性肿瘤之一,仅次于肺癌,位于癌症相关死亡原因第二位.2018年,乳腺癌导致626679人死亡,占所有癌症相关死亡人数的6.6%.同年,新确诊乳腺癌2088849例,同比占11.6%.随着乳腺癌筛查项目的普及和新型抗癌疗法的发展,乳腺癌的发病率和死亡率已显著下降.然而,中国等...
LncRNA-BLACAT2, lncRNA-LET, LncRNA-SLC16A1-AS1, SOX2OT, and LNMAT2 are involved in different key roles in the occurrence and development of bladder cancer8,9,10,11,12. Mechanistically, lncRNAs perform their regulatory functions by acting as ceRNAs against the expression of multiple genes. ...
研究发现,冬凌草甲素联合敲低肌动蛋白丝相关蛋白1-反义RNA1(actin filament-associated protein1 antisense RNA 1,AFAP1-AS1)可抑制人胰腺癌细胞增殖、迁移和上皮间质转化(epithelial-mesenchymal transition,EMT),并在体内抑制裸鼠胰腺癌细胞...
AS1.SLC7A11-AS1是与SLC7A11基因序列互补的反义长链非编码RNA.胱氨酸/谷氨酸反向转运体可摄取胱氨酸,排出谷氨酸.它是一种二硫键连接的异二聚体,由转运体轻链(由SLC7A11基因编码)和伴侣重链亚单位组成.SLC7A11蛋白通过控制胱氨酸摄取,直接调节细胞内的半胱氨酸池,还调节非酶抗氧化成分谷胱甘肽(GSH).SLC7A11的...
lncRNA SLC16A1-AS1 as a novel prognostic biomarker in non-small cell lung cancer. J Investig Med. 2020;68(1):52–9. Article PubMed Google Scholar Zhang R, Ma L, Li W, Zhou S, Xu S. Diagnostic value of multiple tumor-associated autoantibodies in lung cancer. Onco Targets Ther. ...
CCAT1还可通过抑制miR-218/锌指蛋白(zinc finger protein X-linked,ZFX)信号通路促进TNBC细胞增殖、迁移和侵袭[13]。近年来,以LncRNA为靶点的中药有效活性成分抗肿瘤机制的研究日益增多。研究发现,冬凌草甲素联合敲低肌动蛋白丝相关蛋白1-反义RNA1(actin filament-associated protein1 antisense RNA 1,AFAP1-AS1)...
目的探讨LncRNA SLC16A1-AS1通过靶向miR-15a-5p调控子宫颈癌细胞增殖和侵袭的作用机制.方法采用qRT-PCR法检测SLC16A1-AS1在子宫颈癌组织,癌旁组织,人正常子宫颈上皮细胞(H8)及子宫颈癌细胞株(HeLa,HCC94,SiHa,C33A)中的表达水平.选择SLC16A1-AS1表达最少的子宫颈癌细胞株,分别转染阴性质粒和SLC16A1-AS1过...
Furthermore, SLC16A1-AS1 modulates a range of cellular functions, including proliferation, migration, and invasion, through its interactions with diverse molecules and signaling pathways. This review examines the latest evidence regarding the role of SLC16A1-AS1 in the progress...
2.miR-375可能是是影响HCV-HCC患者预后的重要标志物,可作为判断肝癌患者预后的指标. 3.miR-375可以与SLC16A1-AS1联合诊断作为区分丙肝相关肝癌肿瘤组织和非肿瘤组织的潜在的生物标志物. 4.miR-375的表达与癌症的发生发展有关,miR-375可能与lncRNASLC16A1-AS1相互作用对丙肝相关肝癌发挥其生物学功能....
SLC16A1-AS1MiR-5088-5pOral squamous cell carcinomaMaturationOdontology - SLC16A1-AS1 is a newly identified lncRNA with different roles in different cancers. MiR-5088-5p is an oncogenic miRNA in breast cancer. However, their participation in oral squamous...Li, Tiecheng...