LncRNA SLC16A1-AS1miR-182PDCD4乳腺癌是全球女性最常见的恶性肿瘤之一,仅次于肺癌,位于癌症相关死亡原因第二位.2018年,乳腺癌导致626679人死亡,占所有癌症相关死亡人数的6.6%.同年,新确诊乳腺癌2088849例,同比占11.6%.随着乳腺癌筛查项目的普及和新型抗癌疗法的发展,乳腺癌的发病率和死亡率已显著下降.然而,中国等...
研究发现,冬凌草甲素联合敲低肌动蛋白丝相关蛋白1-反义RNA1(actin filament-associated protein1 antisense RNA 1,AFAP1-AS1)可抑制人胰腺癌细胞增殖、迁移和上皮间质转化(epithelial-mesenchymal transition,EMT),并在体内抑制裸鼠胰腺癌细胞...
LncRNA-BLACAT2, lncRNA-LET, LncRNA-SLC16A1-AS1, SOX2OT, and LNMAT2 are involved in different key roles in the occurrence and development of bladder cancer8,9,10,11,12. Mechanistically, lncRNAs perform their regulatory functions by acting as ceRNAs against the expression of multiple genes. ...
lncRNA SLC16A1-AS1 as a novel prognostic biomarker in non-small cell lung cancer. J Investig Med. 2020;68(1):52–9. Article PubMed Google Scholar Zhang R, Ma L, Li W, Zhou S, Xu S. Diagnostic value of multiple tumor-associated autoantibodies in lung cancer. Onco Targets Ther. ...
CCAT1还可通过抑制miR-218/锌指蛋白(zinc finger protein X-linked,ZFX)信号通路促进TNBC细胞增殖、迁移和侵袭[13]。近年来,以LncRNA为靶点的中药有效活性成分抗肿瘤机制的研究日益增多。研究发现,冬凌草甲素联合敲低肌动蛋白丝相关蛋白1-反义RNA1(actin filament-associated protein1 antisense RNA 1,AFAP1-AS1)...
LncRNA 作为内源性的"海绵"或 ceRNA 与 microRNA(miRNA)相互作用,并通过调控下游靶 基因 影响肿瘤 细胞的增殖, 迁移和侵 袭 [39], 如 LncRNA SLC16A1-AS1 通过 miR-552-5p/WIF1 途径 抑制乳腺癌的增殖和转移[37];LncRNA LRP11-AS1 通过 miR-149-3p/NRP2 轴促进 TNBC 细胞的增殖和 迁移[40].在...
Therefore, SLC47A2 is considered a promising diagnostic biomarker strongly associated with the risk of developing RCC. The mechanism underlying SLC47A2 downregulation has been investigated. Gao et al. discovered that the downregulation of a novel lncRNA, SANT1, attenuates its binding affinity to PSF...
(B) Quantitative real-time RT-PCR analyzed the expression of candidate targets (ZNF76, HMGA1, FAM53B, FGFR3, E2F2, HIPK1, SOX12, CDK16, BMF, and SLC16A3) in PRR34-AS1 silenced HCCLM3 cells. (C) ENCORI predicted the binding sites between E2F2/SOX12 and miR-296-5p. (D) ...
2.miR-375可能是是影响HCV-HCC患者预后的重要标志物,可作为判断肝癌患者预后的指标. 3.miR-375可以与SLC16A1-AS1联合诊断作为区分丙肝相关肝癌肿瘤组织和非肿瘤组织的潜在的生物标志物. 4.miR-375的表达与癌症的发生发展有关,miR-375可能与lncRNASLC16A1-AS1相互作用对丙肝相关肝癌发挥其生物学功能....
SLC16A1-AS1MiR-5088-5pOral squamous cell carcinomaMaturationOdontology - SLC16A1-AS1 is a newly identified lncRNA with different roles in different cancers. MiR-5088-5p is an oncogenic miRNA in breast cancer. However, their participation in oral squamous...Li, Tiecheng...