Functional assays revealed that PRR34-AS1 promoted HCC cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) process in vitro and facilitated tumor growth in vivo. In addition, western blot analysis and TOP Flash/FOP Flash reporter assays verified that PRR34-AS1 ...
作者评估了BC患者的风险评分与临床病理特征之间的相关性。低风险组高表达MCF2L-AS1,MAPT-AS1,USP30-AS1,PRR34-AS1和DLGAP1-AS1,而高风险组高表达OTUD6B-AS1,如热图所示(图4A)。风险评分显示BC患者不同临床病理特征的分布模式不同,涉及TNM分期、生存状态、年龄和临床分期(图4B,C)。作者还对不同临床特征亚组...
肝癌组织中 lncRNA-PRR34-AS1 的表达特性及其 对肝癌细胞增殖,迁移的影响和潜在分子机制doi:10.3969/j.issn.1671-7414.2021.06.008魏英王小林Journal of Modern Laboratory Medicine
In liver cancer, the expression of lncRNAs, including PRR34-AS1, SNHG5, lncRNA-DAW, FOXD2-AS1, CTB-193M12.5, lncRNA-CR594175, and lncRNA-MUF is significantly upregulated. Among these, SNHG5 is notably correlated with clinical features such as tumor size, histologic grade, and TNM stag...
研究结果：衰老相关lncRNA标记的构建通过对BC样品中ARGs和lncRNAs表达水平的共表达分析对TCGA-BRCA队列中的患者进行风险评估。利用Cytoscape 3.7.2软件构建了共表达网络图并通过桑基图研究了风险类型、老年人相关基因基因以及相关lncRNA之间的关联(图1D)。最后通过ROC曲线验证了该风险评分模型对乳腺癌患者的良好预测能力...
PRR34-AS1 directly targets microRNA-498 (miR-498) in primary cortical neurons. Importantly, the inhibition of miR-498 expression counteracted the effects of PRR34-AS1 silencing on neuronal apoptosis and inflammation. Conclusions These findings indicate that PRR34-AS1 may be a useful therapeutic ...
Analysis of the TCGA cohort revealed a six aging-related lncRNA signature consisting of MCF2L-AS1, USP30-AS1, OTUD6B-AS1, MAPT-AS1, PRR34-AS1, and DLGAP1-AS1. The time-dependent ROC curve proved the optimal predictability for prognosis in BC patients with areas under curves (AUCs) of...
cancers Communication LncRNA-mRNA Co-Expression Analysis Identifies AL133346.1/CCN2 as Biomarkers in Pediatric B-Cell Acute Lymphoblastic Leukemia Marta Cuadros 1,2,3,†, Daniel J. García 1,2,† , Alvaro Andrades 2,3,4,† , Alberto M. Arenas 2,4 Isabel F. Coira 2,4 , Carlos ...