骨肉瘤组织中MCM3AP-AS1的表达水平升高(P<0.05),miR-335的表达水平降低(P<0.05);转染si-MCM3AP-AS1可明显降低光密度值及Bcl-2蛋白水平,减少克隆形成数,提高凋亡率及Bax蛋白水平(P<0.05);双荧光素酶报告实验证实MCM3AP-AS1可靶向结合miR-335;转染miR-335 inhibitor可明显逆转干扰MCM3AP-AS1对U2OS细胞增殖及...
对于IV组,MIAT和MCM3AP-AS1在接种后第1天下调。LINC01133和DANCR分别在疫苗接种后第3天和第7天上调。在所有组群中,蛋白质编码基因TNFRSF17在IV后第7天被上调。对于YF-17D疫苗接种的队列,差异表达的lncRNA包括AATBC,MAPKAPK5-AS1和LRRC75A-AS1。疫苗接种后IFN刺激基因表达的增加是YF-17D反应的标志,在第7天检...
Long non-coding RNAs (lncRNAs) are a class of RNA molecules with transcripts longer than 200 nucleotides that have no protein-coding ability. MCM3AP-AS1, a novel lncRNA, is aberrantly expressed i
重要的是,鉴定了AC013652.1和 MCM3AP-AS1抑制双硫死亡,可作为COAD的潜在治疗靶点。
Moreover, MCM3AP-AS1 knockdown induced proliferation inhibition, G1 arrest and apoptosis of HCC cells [123]. CASC2 not only regulates EMT through miR-367/FBXW7 axis [67], but also take part in the regulation of cell cycle. By quantitative real-time polymerase chain reaction, Gao et al....
A novel lncRNA MCM3AP-AS1 promotes the growth of hepatocellular carcinoma by targeting miR-194-5p/FOXA1 axis. Mol Cancer. 2019;18(1):28. Article PubMed PubMed Central Google Scholar Pan F, Lin XR, Hao LP, Chu XY, Wan HJ, Wang R. The role of RNA methyltransferase METTL3 in ...
with higher expression indicating longer survival. A disulfidptosis-related lncRNA signature comprising four lncRNAs was established based on the expression of these genes. Among these, AC013652.1 and MCM3AP-AS1 predicted worse prognoses. Furthermore, inhibiting AC013652.1 or MCM3AP-AS1 increased dis...
肝硬化是全球范围内的高发病和多发病，严重者可能会出现肝性脑病、肝肾综合征、上消化道大出血、肝癌等并发症，进而威胁患者生命安全［2-3］。目前，肝硬化的发病机制仍不完全清楚。因此，深入探索肝硬化发生、发展相关的生物标志物，对其早期诊断意义重大。长链非编码 RNA（lncRNA）是一类长度超过200个核苷酸的RNA...
YY1 acts as an activator to promote lncRNA MCM3AP-AS1 in LUAD23. Our study revealed that YY1 inversely regulated the expression of lncRNA UPLA1 using qRT-PCR and luciferase reporter assays. Therefore, we found that YY1 could also act as a tumour suppressor in LUAD. This finding sheds ...
A novel lncRNA MCM3AP-AS1 promotes the growth of hepa- tocellular carcinoma by targeting miR-194-5p/FOXA1 axis. Mol Cancer. 2019;18(1):28. 13. Pan F, Lin XR, Hao LP, Chu XY, Wan HJ, Wang R. The role of RNA methyl- transferase METTL3 in hepatocellular carcinoma: results and ...