The liver-on-a-chip (LoC) is one such potential device that suits the necessity in the field of drug designing and toxicity screening studies. LoC also performs as a platform of in vitro disease models to explore toxicity and pharmacokinetic analysis of drugs. There are different microfluidic ...
liver-on-a-chipreconstructionapplicationsThe considerable advances that have been made in the development of organotypic cultures have failed to overcome the challenges of expressing tissue-specific functions and complexities, especially for organs that require multitasking and complex biological processes, ...
The goal is to compare these engineered organs to animal models, with an eye towards replacing animal testing.
Judging the value of `live-on-a-chip' devices for prediction of toxicity. Expert Opin. Drug Metab. Toxicol. 2017, 13, 125-128. [CrossRef] [PubMed]Starokozhko V, Groothuis GM. Judging the value of `liver- on-a-chip' devices for prediction of toxicity. Expert Opin Drug Metab ...
Here, we present an integrated-gut-liver-on- a-chip (iGLC) platform as an in vitro human model of the gut-liver axis (GLA) by co-culturing human gut and liver cell lines interconnected via microfluidics in a closed circulation loop, for the initiation and progression of NAFLD by ...
However, due to the absence of reliable platforms, the transportation, uptake, and damage of microplastics in the gut-liver axis remain unclear. Here, we present the development of a gut-liver-on-a-chip (GLOC) featuring biomimetic intestinal peristalsis and a dynamic hepatic flow environment, ...
We report on the development of an integrated microfluidic and multi-electrode array (MEA) system housed in a microbioreactor for Body-on-a-Chip applications. On a single chip, we successfully demonstrate the use of this system by connecting an on-Chip Liver and an on-Chip Heart. We demonst...
"This platform is unique in that in one continuous liver tissue on asingle chip, we are able to look at different severities of the disease and to study how liver tissue might respond to both triggers of NAFLD as well as different therapeutic approaches," said senior author O. Berk Usta,...
Here, we introduce the concept of "body-on-a-chip," with a specific emphasis on recapitulating the interaction between the gut and the liver, which play important roles in many diseases, as well as responses to drugs. 展开 关键词: Body-on-a-chip Gut-liver chip Microphysiological systems ...
Here we have simulated the oral uptake of 50 nm carboxylated polystyrene nanoparticles with a microscale body-on-a-chip system (also referred to as multi-tissue microphysiological system or micro Cell Culture Analog). Using the 'GI tract–liver–other tissues' system allowed us to observe ...