Liver sinusoid on a chip: long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms. Biotechnol Bioeng. 2015;112:2571-2582.Kang, Y.B.; Sodunke, T.R.; Lamontagne, J.; Cirillo, J.; Rajiv, C.; Bouchard, M.J.; Noh, M. L...
Liver sinusoid on a chip: long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms Biotechnol Bioeng, 112 (2015), pp. 2571-2582 CrossrefView in ScopusGoogle Scholar 106 L. Prodanov, R. Jindal, S.S. Bale, M. Hegde, W.J. McCarty, I. Golber...
These HLCs are integrated into various culture systems including 2D culture, 3D organoids or spheroids, bioprinted tissue constructs, and liver-on-a-chip (microfluidic) devices. The culture systems can then be used to model various liver diseases including HBV, HCV, malaria, NAFLD, ALD, and ...
Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applicationshepatocyteliver-on-a-chip... M Ortega-Ribera,A Fernandez-Iglesias,X Illa,... - 《Biotechnology & Bioengineering》 被引量: 0发表: 2018年 An artificial liver sinusoid with a microfluidic endoth...
Human liver sinusoid on a chip for hepatitis b virus replication study. Micromachines 2017, 8, 27. [Google Scholar] [CrossRef] [Green Version] Song, M.J.; Yun, D.H.; Min, N.K.; Hong, S.I. Electrochemical biosensor array for liver diagnosis using silanization technique on nanoporous ...
In one week, these clusters were gradually connected, assembled, and organized into an organotypic architecture, which could be identified to the typical sinusoid wall-like morphology and the fenestrated window-like nanostructure. Figure 4: scheme of the organization and form of a liver lobule. ...
A flexible microfluidic platform would also support the assembly of a more advanced organs-on-a-chip device, further bridging gap between in vitro and in vivo conditions. The standard transcriptomic analysis of these cell systems can be complemented with causality-inferring approaches to improve the ...
Moreover, they indicated that some cell crosstalk occurs during the early formation of the sinusoid. Overall, these results generated a comprehensive map of a primitive liver cell lineage from the endoderm and mesoderm. The liver is structurally and metabolically zonated, which forms the basis for...
(hepatocytes, endothelial cells, stellate cells and Kupffer cells). Leeet al.44fabricated a PDMS device which mimics the liver anatomy. The device features an artificial liver sinusoid with an artificial barrier layer mimicking endothelial barrier layer. We have also integrated cell lines and primary...
However, liver chip platforms have provided new opportunities to study viral hepatitis in a more physiological environment. Even using animal liver cells, valuable data have been obtained on viral infection. A rat liver sinusoid chip system, for example, was applied for the first time in 2015 to...