In the discussion, an overview of the major abnormalities reported in the literature is presented, and some specific questions regarding 1) perisinusoidal fibrosis in liver with normal histology, 2) the overload of perisinusoidal cells with lipids in non-hypervitaminosis A intoxication and 3) the...
Liver fibrosis can be reversed by removing its causative injuries; however, the molecular mechanisms mediating the resolution of liver fibrogenesis are poorly understood. We investigate the role of a scaffold protein, A-Kinase Anchoring Protein 12 (AKAP12), during liver fibrosis onset, and resolution...
Laboratory for Cell Biology and Histology, Free University of Brussels (VUB), Laarbeeklaan 103, 1090 Brussels, Belgium15th international congress on electron microscopy, vol. 2. Life sciences: 15th international congress on electron microscopy(ICEM-15), 1-6 September, 2002, Durban, South Africa...
Liver fibrosis was induced by intraperitoneal injection of carbon tetrachloride (CCl4) with or without curcumin for 6 weeks. The results suggest that curcumin treatment markedly attenuated CCl4-induced liver fibrosis, as assessed by histology and hydroxyproline content, and inhibited hepatic stellate ...