nonalcoholic fatty liver disease (NAFLD)liver-on-a-chipArticle2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The liver possesses a unique microenvironment with a complex internal vascular system and cell–cell interactions. Nonalcoholic fatty liver disease (NAFLD) is the most common form of ...
1, Osamu Tabata1,5,7 & Ken-ichiro Kamei 5,8,9,10 ✉ Non-alcoholic fatty liver disease (NAFLD) afflicts a significant percentage of the population; however, no effective treatments have yet been established because of the unsuitability of in vitro assays and animal experimental models. Here...
including the use of spheroid cultures and organ-on-a-chip models, have provided us with tools to better recapitulate the complex in vivo liver morphology and to study the interplay between parenchymal and non-parenchymal liver cells important for disease development, including processes of hepatocyte...
However, a deep understanding of NAFLD progression remains challenging due to the lack of proper in vitro human disease models. In this work, we proposed a new strategy to establish a human NAFLD model based on a human-induced pluripotent stem cell (hiPSC)-derived liver organoids-on-a-chip ...
This review article presents the latest research on nonalcoholic fatty liver disease (NAFLD) in vitro modeling. Benefits and limitations of using human induced pluripotent stem cell-derived approaches, primary organoids, liver-on-a-chip, and precision-cut liver sections are discussed to help research...
we examine the progress of research on DILI, enumerate in vitro models with potential benefits, and highlight cellular molecular perturbations that may serve as biomarkers. Additionally, we discuss omics approaches frequently used to gather comprehensive datasets on molecular events in response to drug ...
8:10 FEATURED PRESENTATION: The Epidemic of Fatty Liver Disease: Silent, Serious and Still Growing? Lee Kaplan, M.D., Ph.D., Director, Obesity, Metabolism and Nutrition Institute, Massachusetts General Hospital, Harvard Medical School Silent, Serious and Growing Obesity the Disease = BMI>30: ...
Moreover, organ-on-a-chip models simulate real synthetic microenvironments, integrating living cells that can mimic the in vitro functions of an organ. New studies have successfully replicated the connection of several organ-on-a-chips to create body-on-a-chip models that represent multi-organ ...
Once these improvements have been made, a lot of diseases, like the hepatitis B, will benefit from this liver-on-chip. Other diseases have already been tested on this kind of microdevice. This is the case for the Nonalcoholic fatty liver disease (NAFLD), which is the most common liver ...
Here, we introduce the concept of “body-on-a-chip,” with a specific emphasis on recapitulating the interaction between the gut and the liver, which play important roles in many diseases, as well as responses to drugs. Introduction Current cell-based in vitro models of diseases carry an ...