Enzyme-inducing drug combinations and their effects on liver microsomal enzyme activity in man. European Journal of Clinical Pharmacology 1983;24(2):247e50.OHNHAUS, E.E.; GERBER-TARAS, E.; PARK, B.K. Enzyme-inducing drug com- binations and their effects on liver microsomal enzyme activity ...
Spheroids produced through non-scaffold growth methods are typically uniform in both size and shape. In comparison to monolayer cultures, all hepatocyte spheroids exhibit consistently higher levels of albumin and urea secretion, as well as phase I and II metabolic enzyme activities and transport factor...
and defense functions. The liver is the primary organ for drugmetabolismand thus is exposed to drugs and metabolites rapidly after gastrointestinal absorption. The gold standards used preclinically and clinically to monitor hepatotoxicity are theliver enzymesALT (alanine aminotransferase), and AST (aspart...
Considering the characterization of vitamin D deficiency as a risk factor of ectopic fat deposition, the association of serum 25-hydroxy vitamin D3 [25(OH)D3] levels with non-alcoholic fatty liver disease (NAFLD) was evaluated in Chinese men with normal body mass index (BMI) and enzyme marke...
98 Cytochrome P450 2E1, an enzyme in the ER and mitochondria of hepatocytes, additionally bolsters these products by metabolizing alcohol to acetaldehyde in the presence of oxygen and NADPH.99 Stimulated by chronic alcohol consumption, cytochrome P450 2E1–led alcohol metabolism is another pathway ...
(intracellular adhesion molecule 1), CXCL9 (T-cell chemoattractant/Chemokine ligand 9), IL8 (Interleukin/Chemokine ligand 8), CD38 (multifunctional ectoenzyme CD38 molecule), VDR (Vitamin D receptor), NRF2 (antioxidant nuclear transcription factor 2), and HLA-DR (MHC Class II cell surface ...
Genetic epidemiology of environmental toxicity and cancer susceptibility: human allelic polymorphisms in drug-metabolizing enzyme genes, their functional i... Pharmacogenetics is the study of idiosyncratic drug responses that have an hereditary basis and usually reflect differences in drug-metabolizing enzymes...
Enzyme levels in media The supernatant was extracted after exposed to 0 and 20 mM NH4Cl for 12, 24 and 48 h respectively. The detection of each indicator was carried out in accordance with the requirements of the ELISA kit. The OD values were detected at 450 nm with a Microplate reader ...
Alike, this miRNA targets fatty acid synthase and the enzyme catalyze the synthesis of long-chain saturated fatty acids. Among the top 10 miRNAs is let-7b-5p known to influence translation of insulin receptor substrate 2 transcripts and this protein functions as an adaptor to link receptor ...
Induction of oxidative DNA damage by NOD isolated from a field sample (1, 2.5, 5 and 10 μg/ml), was shown in HepG2 cells, using the modified comet assay with fpg enzyme that catalyzes the excision of oxidized purines [141]. The highest level of DNA strand breaks was reached after ...