As an abundant source of human hepatocytes, iPSC-HLCs exhibit comparable phase II enzyme expression to HepG2, and a similar metabolite profile to HepaRG [54,55]. Furthermore, the sensitivity of HLCs to various hepatotoxic compounds and the response to AHR agonists are similar to those of PHH...
The interactions of drug metabolizing enzyme inducers, inhibitors, and substrates with washed liver microsomes and a solubilized cytochrome P 450 were investigated using spectral shift techniques. Results indicate that the microsomal enzyme inducer, phenobarbital, binds to microsomes and to soluble cytochrome...
As an abundant source of human hepatocytes, iPSC-HLCs exhibit comparable phase II enzyme expression to HepG2, and a similar metabolite profile to HepaRG [54,55]. Furthermore, the sensitivity of HLCs to various hepatotoxic compounds and the response to AHR agonists are similar to those of PHH...
and Buonocore, V. (1987). Effect of liver enzyme inducers on metabolite excretion in rats treated with 1-nitroyrene. Toxicol. Lett., 36 , 233.Belisario, MA, Carrano, L., DeGlulio, A., Pecce, R. and Buonocore, V. (1987). Effect of liver enzyme inducers on metabolite excretion in ...
et al. A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization. J. Biol. Chem. 284, 11942–11952 (2009). Article CAS PubMed PubMed Central Google Scholar Mandar...
Experimental strategies have long been applied for in vitro or in vivo evaluation of the effect of transporters and/or enzymes on the bioavailability. However, the lack of specific inhibitors or inducers of transporters and enzymes and the multiplicity of nuclear receptors in gene regulation and cros...
1983), and hyperplasia (increase in cell number) (van der Oost et al. 2003). They are usually associated with the induction or stimulation of hepatic enzyme activities (Kosmala et al. 1998). Larger liver mass relative to body mass, caused by the increased metabolic activity to detoxify ...
2020Computational Modelling of Midazolam Clearance: Effect of Inhibitors and Inducers Yannick Duport (supervisor:Matthias König) Bachelor Thesis, August 2020 2020 PK-DB: pharmacokinetics database for individualized and stratified computational modeling ...
Generally, some substances may act as inducers, increasing the levels of the enzymes, while others may act as inhibitors, decreasing the levels of the enzymes. Both are important to consider. Inducers Those substances that induce greater production of liver enzymes have an important effect on the...
2020Computational Modelling of Midazolam Clearance: Effect of Inhibitors and Inducers Yannick Duport (supervisor:Matthias König) Bachelor Thesis, August 2020 2020 PK-DB: pharmacokinetics database for individualized and stratified computational modeling ...