Drug-induced liver injury (DILI) refers to drug-mediated damage to the structure and function of the liver, ranging from mild elevation of liver enzymes to severe hepatic insufficiency, and in some cases, progressing to liver failure. The mechanisms and clinical symptoms of DILI are diverse due ...
LIVER diseasesWOUNDS & injuriesSKELETAL muscleANDROGEN receptorsAnabolic steroids are well-known to cause liver injury, which may manifest with jaundice and elevated liver enzymes. Selective androgen receptor modulators (SARMs) have been developed to enhance muscle bulk without the side effects associated ...
the authors evaluated five clinical trials to evaluate hepatic adverse events [69]. They found that 90% of patients had some degree of elevated liver enzymes; however, 61% of
Liver disease in pregnancy can be classified as predating, co-incidental or unique to pregnancy. Medications are often overlooked as a significant cause of liver disease. We present the case of a 39-year-old patient who presented at 20 weeks with jaundice, elevated liver enzymes, and abnormal...
来源期刊 American family physician 2011-08-01 研究点推荐 Elevated Liver Enzymes Hep C Drug 站内活动 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术服务。在这里我们保持学习的态度,不忘初心,砥砺前行。了解更多>> 友情链接 联系我们 ...
An induction of hepatoxicity by elevated liver enzymes due to psychotropic drug treatment was reported for antidepressants, antipsychotics, mood stabilizers, and anxiolytic agents9. In an animal study, adverse effects after psychotropic drug treatment on the liver were shown10. Sprague-Dawley rats ...
Arm 2: prior TKI but no chemotherapyArm 2: 20 150 mg daily G3 elevated liver enzymes (n = 2), diarrhoea (n = 2), weight loss (n = 1). No G4 toxicities. Arm 2: Sequist et al (Ahn et al., 2016; Anon., 2016)Ib Part A (dose escalation): TKI treated Part A: 23 Part ...
Drug resistance represents a significant obstacle in cancer treatment, underscoring the need for the discovery of novel therapeutic targets. Ubiquitin-specific proteases (USPs), a subclass of deubiquitinating enzymes, play a pivotal role in protein deubi
Drug-induced liver injury (DILI) is an important clinical problem, which has received more attention in recent decades. It can be induced by small chemical
•Define the various superfamilies, subfamilies, and individual drug-metabolizing enzymes and their tissue expression in humans. •Identify the role of the major drug-metabolizing enzymes in the disposition of medication and other xenobiotics...