Enzyme InductionLevonorgestrelThe CEU Guidance on drug interactions with hormonal contraception includes discussion on progestogen-only emergency contraception in women using liver enzyme-inducing drugs. In Table 2 of page 145 I read: "Take a total dose of 2.25 mg levonorgestrel as a single dose as ...
Here, we sought to determine what effects DM1 might have on hepatic functions and overall liver health. Utilizing two previously established mouse lines, we generated a mouse model in which we induced the expression of (CUG)960repeat-containing RNA, specifically in the hepatocytes within the liver...
elevated liver enzymeconcentrations are the only indicators of disease. Thorough investigation of abnormalliver function testsis therefore essential to produce a diagnosis at a stage where the underlying disease is likely to be treatable. Clinical stigmata ofchronic liver diseaseare not present in the...
Here, we sought to determine what effects DM1 might have on hepatic functions and overall liver health. Utilizing two previously established mouse lines, we generated a mouse model in which we induced the expression of (CUG)960repeat-containing RNA, specifically in the hepatocytes within the liver...
98 Cytochrome P450 2E1, an enzyme in the ER and mitochondria of hepatocytes, additionally bolsters these products by metabolizing alcohol to acetaldehyde in the presence of oxygen and NADPH.99 Stimulated by chronic alcohol consumption, cytochrome P450 2E1–led alcohol metabolism is another pathway ...
(up to 14 days) and low-dose exposure to several DILI-inducing drugs (Ware et al.2017). The authors found that these hepatotoxins led to a greater number of DEGs in the co-culture modes compared to their non-liver-toxic analogs. They also pointed out the transcriptome changes in fatty ...
Modelling complex liver diseases including nonalcoholic steatohepatitis (NASH) is now possible using differentiated human pluripotent stem cells to produce functional bile canaliculi systems disrupted by cholestasis-inducing drugs such as troglitazone. Additionally, dysregulation of biliary- and hepatocyte-...
However, a recent study has indicated that DSB induction by controlled expression of the restriction enzyme SacI in the mouse liver induces features of tissue aging in 2 months post DNA double-strand breakage, but no tumors was reported [64]. SacI targets ∼130,000 sites accessible for ...
aRepresentative images of the livers from different groups. Scale bar = 1 cm.b,cSerum ALT and AST enzyme levels from different groups (**P < 0.01,n = 5).dRepresentative Western blot of Lc3b, Cleaved Caspase 3, Atg16l1, and Eva1a in the liver extracts obtained from diff...
a key enzyme catalyzing the terminal step in triacylglycerol synthesis as well as AGPAT isoforms involved in the metabolism of lysophosphatidic acid to phosphatidic acid (PA). The latter are important signalling molecules but also function as building block intermediates in lipid biosynthesis. Other ...