Plasma protein binding of dexlansoprazole ranged from 96 to 99% in healthy subjects and was independent of concentration from 0.01 to 20 mcg/mL. The apparent volume of distribution (Vz/F) after multiple doses in symptomatic GERD patients was 40 L. Elimination Metabolism Dexlansoprazole is extensive...
EGFR is a protein that is found on the surface of some cells that causes cells to divide when epidermal growth factor binds to it. EGFR is found at abnormally high levels in cancer cells, and EGFR activation appears to be important in tumor growth and progression. Some types of cancers sho...
Protein binding affinity: https://bitbucket.org/wenxiu/sequence-shape.git Change in local frustration index: https://github.com/gersteinlab/frustration TFImpute: multi-task learning from ChIP-seq data across factors and tissues to impute TF binding for an unassayed tissue/factor combination: https...
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FDA Approved Drugs– 1891 compounds Compounds in Clinical Trials– 1977 compounds Approved non FDA Drugs– 1062 compounds Complete Stock Database of Drugs and Inhibitors– 45214 compounds Repurposing Library– 4541 compounds Small Molecule Inhibitors– 52984 compounds ...
The plasma protein binding of linezolid is approximately 31% and is concentration-independent. The volume of distribution of linezolid at steady-state averaged 40 to 50 liters in healthy adult volunteers. Linezolid concentrations have been determined in various fluids from a limited number of subjects...
This page describes the Chemistry Academic Word List (CAWL), giving information on what the CAWL is, details about how it was developed, information on text coverage of the CAWL, mentions some problems with the published list, as well as giving a complete list of words in the CAWL. To exp...
The first module of this course will focus on introducing the concept of personalized medicine. We will very briefly review fundamentals of genetics as these apply to personalized medicine (DNA structure; RNA; protein structures; function of DNA; coding; DNA variations; types of genetic variants),...
ACACIAS 46CH-1211 GENF 24SWITZERLANDDR. MICHEL AUBAILLYLAB. DE PHYSICO-CHIMIE DEL'ADAPTATION BIOLOGIQUE43 RUE CUVIERF-75231 PARIS CEDEX 05FRANCEDR. JUNE E. AYLINGUNIVERSITY OF SOUTH ALABAMADEPARTMENT OF PHARMACOLOGYCOLLEGE OF MEDICINEMOBILE, AL 36688USADR. ADELBERT BACHERORGAN. CHEMIE UND BIOCH....