(in mg/kg) should be lower in neonates and infants with low albumin because of both decreased protein binding as well as decreased elimination by renal and/or hepatic metabolism. Examples of high ER drugs that are highly protein bound (ie, >70%) with narrowtherapeutic windowsincludealfentanil,...
Such studies have laid the foundation for discovering drugs that selectively disrupt specific ATG8–LIR interactions. Download: Download high-res image (694KB) Download: Download full-size image Figure 2. Structural features of ATG8 family proteins and two examples of LC3 inhibitors. (A) ...
This article uses examples to describe general strategies in the development of small molecule antagonists of protein–protein interactions. Two types of antagonists are described: those that bind directly to the 'hot spot'of a protein–protein interface — a region that has a major contribution to...
Interactions between proteins, drugs, and other biomolecules play a crucial role in various biological processes1,2,3. Understanding these interactions is essential for deciphering the molecular mechanisms underlying biological processes and developing new therapeutic strategies4. However, the massive growth ...
VCP hexamers can associate with different cofactors at the same time. However, some cofactor combinations are mutually exclusive [127]. As such, binding of UBX domains (examples: UBXN7, UBXN8) will preclude the interaction with VIM motifs (present in AMFR and SELENOS) [154]. Table S2provides...
Classification of protein–protein interaction types based on affinity and stability. Stable complex (PDB: 1 F34) Structure of Ascaris pepsin inhibitor-3 bound to Porcine pepsin; Transient Domain-Domain interaction (PDB: 1AY7) Structure of the Ribonuclease SA Complex With Barstar; Transient Domain...
Protein-protein interactions (PPIs) are central to a variety of biological processes, and their dysfunction is implicated in the pathogenesis of a range of human diseases, including cancer. Hence, the inhibition of PPIs has attracted significant attentio
Because the majority of drugs are bound toplasma proteinsor tissuebinding sites, the most commonly cited mechanisms for drug–drug interactions affecting distribution are those that involve protein or tissue binding. Several examples exist in which one drug displaces an object drug through competitive ...
They can provide atomic-resolution or near-atomic-resolution structures of the unbound proteins and the protein–ligand complexes, which can be used to study the changes in structure and/or dynamics when binding happens, along with between relevant free and bound forms [56]. However, a high ...
including participants with elevatedtriglyceride levelsand elevated low-density lipoprotein cholesterol. From the analysis of cohorts, the study reported a statistically significant 18% reduced risk for CHD[52]. On the other hand, there are examples of studies such as the metaanalysis of Aung et al...