(1977). Plasma protein bind- ing of basic drugs. II. Importance of a,-acid glyco- protein for interindividual variation. Clin. Pharmac. Ther., 22, 545-549.Piafsky, K. M., Borgâ, O.: Plasma protein binding of basic drugs. II. Importance of α 1 -acid glycoprotein for ...
in neonates, these drugs have displaced bilirubin from plasma protein-binding sites. This has resulted in hyperbilirubinemia and kernicterus (brain damage caused by bilirubin). In addition, numerous examples of drug-drug interactions involving warfarin and other highly protein-bound drugs exist in the ...
Protein binding was determined by equilibrium dialysis (drugs) or by a reaction rate method (bilirubin), using serum and plasma obtained from the same animals. The three drugs were significantly less protein bound in heparinized plasma than in serum; this difference was particularly pronounced in ...
Often the total protein concentration is within the reference range, whereas the A/G ratio is decreased, therefore the A/G ratio is of greater clinical significance than the total protein concentration. Examples of diseases with a decrease in the A/G ratio are egg related peritonitis and ...
Overall, this study provides plasma protein dynamic changes throughout the cetuximab therapy course at an individual patient level, and identifies the potential biomarkers for tumor diagnosis, the initial response prediction and longitudinal response prediction, revealing the heterogeneity of these different ...
Potential drugs to target deregulated proteins in COVID-19 patients with severe complication Fig. 4: Drug–protein interactions of upregulated plasma proteins in severe COVID-19 patients. Full size image The molecular severity score: a 12-protein signature for COVID-19 severity ...
Chandy T and Sharma C P 1987 Polym. Plast. Technol. Engg. 26 143Chandy. T and Sharma C.P., Protein-polymer interaction-Changes with plasma components, vitamins and antiplatelet drugs at the interface, Polym. Plast. Tech. Engg., 26, 143–227 (1987)....
Homology modeling was critical for this project because, as a large transmembrane protein, ScPma1p has been difficult to isolate and crystallize. To create the ScPma1p model, we used the Na+, K+-ATPase from Sus scrofa as a structural template (PDB 3N2F, chain C) [20]. Per a Clustal ...
Our main objective was to identify plasma host protein biomarkers that change over time prior to developing TB in people living with HIV (PLHIV). Methods Using multiplex MRM-MS, we investigated host protein expressions from 2 years before until time of TB diagnosis in longitudinally collected (...
Protein binding of drugs in plasma are of special interest in pharmacological studies because only the drug that is unbound to plasma proteins (i.e., is “free”) has access to target tissue and hence is biological active18. PET imaging of the brain with radiolabeleld ligands faces the same...