ClodronateA study was undertaken to determine if the intravenous injection of liposome-encapsulated dichloromethylene diphosphonate (C12MDP; Clodronat), a treatment known to deplete monocytes, as well as liver and spleen macrophages, would reduce the number of macrophages in the retina of animals ...
A study was undertaken to determine if the intravenous injection of liposome-encapsulated dichloromethylene diphosphonate (C12MDP; Clodronat), a treatment known to deplete monocytes, as well as liver and spleen macrophages, would reduce the number of macrophages in the retina of animals with experim...
Liposome-encapsulated clodronate (LEC) is a specific depletor of macrophages. Our study characterized the LEC depletory effects, given intrathecally, on spinal microglia and assessed its effects on initiation and maintenance of neuropathic pain. Measured by using the MTT assay, LEC treatment specifical...
Clodronate encapsulated in liposomes is also toxic to macrophages in vivo and may therefore be of use in the treatment of inflammatory diseases. It is generally believed that bisphosphonates are not metabolized. However, we have found that mammalian cells in vitro (murine J774 macrophage-like cells...
Immunotherapy with clodronate-encapsulated liposomes, which induce macrophage depletion, has been studied extensively. However, previously reported liposomal formulation-based drugs (Clodrosome® and m-Clodrosome®) are limited by their inconsistent
Define Liposomes. Liposomes synonyms, Liposomes pronunciation, Liposomes translation, English dictionary definition of Liposomes. n. A microscopic artificial vesicle consisting of an aqueous core enclosed in phospholipid molecules, used to convey vaccine
英文名:Lyophilized-Clodronate Liposomes (Neutral) 中文名:冻干粉氯膦酸二钠脂质体(中性) Clodronate disodium (liposome encapsulated): 5 mg/mL Lipid composition: phosphatidylcholine and cholesterol Shelf-life: 12 months for dry cake (guaranteed, replacement only) ...
Liposomal clodronate eliminates synovial macrophages, reduces inflammation and ameliorates joint destruction in antigen-induced arthritis OBJECTIVES: To investigate the efficacy of a single i.v. dose of clodronate encapsulated within small unilamellar vesicles in suppressing joint inflammatio... Richards,J P...
Different macrophage subsets are present in the spleen, i.e., marginal zone macrophages (MZM), marginal metallophilic macrophages (MMM) and red pulp macrophages (RPM) and all are depleted by a single treatment with liposome-encapsulated clodronate. These macrophages can be distinguished by differences...
Non-encapsulated clodronate cannot cross the cell membrane to initiate cell death. Control liposomes (Encapsome®) are recognized and phagocytosed by the same mechanism as Clodrosome®. Since the control liposomes do not contain clodrona...