Clodronate-loaded liposomes were used as a tool to deplete macrophages in C57BL/6J mice and assess oral osseous bone fill after extraction. In addition to macrophage ablation, osteoclast ablation occurred. Interestingly, depletion of macrophages and osteoclasts via clodronate treatment had differential ...
In this paper we used the design of experiments to study the influence of various factors on the formulation of clodronate loaded liposomes. These variables were phosphatidylcholine to cholesterol ratio, the lipid component to active substance ratio and sonication time. The selected responses were drug...
liposomes; doxorubicin; clodronic acid; magnetic nanoparticles; intralipid; blood circulation time; pharmacokinetics; MPS clearance; macrophages; red blood cells1. Introduction Nanomaterials offer tremendous potential for numerous biomedical applications such as biosensing [1], transfection [2], bioimaging [...