ResearchOpen Access23 Nov 2024Nature Communications Volume: 15, P: 10168 UGT8 mediated sulfatide synthesis modulates BAX localization and dictates apoptosis sensitivity of colorectal cancer Le Zhang Prashanthi Ramesh Jan Paul Medema ResearchOpen Access23 Nov 2024Cell Death & Differentiation ...
Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they
These newly synthesized lipids may support a number of cellular processes to promote cancer cell proliferation and survival. Hence, de novo lipogenesis is under intense investigation as a therapeutic target. Epidemiologic studies suggest dietary fat may also contribute to prostate cancer; however, ...
This interesting research article highlights “a novel underlying mechanism, why consuming PL-rich foods such as fish and dairy may reduce the risk of developing dementia and associated disorders.” Read full articlehere. Call for Papers: Environmental Exposures and Lipid Homeostasis: Investigating the...
To account for the large number of highly correlated metabolic measures, we used a false discovery rate correction (14) and interpreted false discovery rate–corrected p values <0.05 as providing evidence against the null hypothesis. To test the added discriminatory power of these metabolic measures...
As of yet, NPM has not been fully elucidated as to its cause. Even though NPM is benign and self-limiting, it is increasingly valued. On the one hand, the differentiation between NPM and breast cancer is still an urgent problem to be solved; on the other hand, it can cause extensive ...
Throughout the biological world, a 30 A hydrophobic film typically delimits the environments that serve as the margin between life and death for individual... G Van Meer,DR Voelker,GW Feigenson - 《Nature Reviews Molecular Cell Biology》 被引量: 4569发表: 2008年 Meta-analysis of the effects...
Fatty acid desaturation is central to metazoan lipid metabolism. Here, usingC. elegansas a model, the authors show that both endogenous and microbiota-dependent small molecule signals converge to promote lipid desaturation via the nuclear receptor NHR-49/PPARα. ...
Cell Death and Differentiation (2002) 9, 234 ± 236 ã 2002 Nature Publishing Group All rights reserved 1350-9047/02 $25.00 www.nature.com/cdd News and Commentary Lipids, cardiolipin and apoptosis: a greasy licence to kill M Degli Esposti*,1 1 Cancer Research Campaign Molecular Pharmacology ...
In contrast with the traditional view that LDs are simple lipid storage vesicles, because of their dynamic nature and multifunctionality they are today accepted as a distinct intracellular organelles. Recent studies underline physiological importance of these multifunctional organelles, particularly in the co...