Fatty acid desaturation is central to metazoan lipid metabolism. Here, usingC. elegansas a model, the authors show that both endogenous and microbiota-dependent small molecule signals converge to promote lipid desaturation via the nuclear receptor NHR-49/PPARα. ...
Still, the initial results could have a significant clinical impact, given how aggressive many KRAS-dependent cancers, such as pancreatic cancer, tend to be. Based on their findings, the team suggests that drug and dietary interventions that stunt sphingolipid production may help increase the efficac...
Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they
This interesting research article highlights “a novel underlying mechanism, why consuming PL-rich foods such as fish and dairy may reduce the risk of developing dementia and associated disorders.” Read full article here.Call for Papers: Environmental Exposures and Lipid Home...
Chapter 6 provides information on substances of lipid origin that have had important effects for the treatment or prevention of diseases such as cancer, diabetes mellitus, cardiovascular disorders, obesity, among others. Information associated with metabolites of plant origin, as well as lipids of anim...
Lipidomes, benefiting from their self-assembly process with inherent thermodynamic advantages, have emerged as a versatile tool in cancer therapy. They have been harnessed to enhance tumor targeting efficacy, minimize off-target toxicity [17], and treat patients with severe infections or compromised ...
LDL and HDL have therefore been proposed as a carrier for the water-insoluble anti-cancer agents. Introduction Liver is one of the most important organs in energy metabolism. Most plasma apolipoproteins, endogenous lipids and lipoproteins are synthesized in the liver [1,2], which depends on the...
2.2. Alterations of Lipogenesis in Cancer While the excessive anaerobic metabolism of glucose, i.e., the Warburg effect [36,37] in cancer cells has been well described, as a major mean to provide energy for proliferation and survival [38], less is known in terms of lipid synthesis in canc...
cancer stem cells, ovarian cancer cells, blood vessels and extracellular matrix (ECM), required for tumor growth and metastasis. Alteration in lipid profiles were found in ovarian tumor and plasma samples of patients having ovarian cancer as summarized in figure above.Significant increase in sulphatid...
These newly synthesized lipids may support a number of cellular processes to promote cancer cell proliferation and survival. Hence, de novo lipogenesis is under intense investigation as a therapeutic target. Epidemiologic studies suggest dietary fat may also contribute to prostate cancer; however, ...