Cancer cells frequently display specific alterations in their metabolic activity. Reprogramming of lipid metabolism is now a recognized hallmark of malignancy, and reactivation of fatty acids (FA) and cholesterol biosynthesis is frequently observed in cancer tissue. Lipids exert an essential role in ...
Metabolic reprogramming, a hallmark of cancer, allows cancer cells to adapt to their specific energy needs. The Warburg effect benefits cancer cells in both hypoxic and normoxic conditions and is a well-studied reprogramming of metabolism in cancer. Interestingly, the alteration of other metabolic pat...
There is emerging evidence that lipids and lipid metabolism are essential for cancer growth. In hepatocellular carcinoma a decline of apoptotic lipids like ceramides is supposed to hinder death of cancer cells. Accumulation of saturated fats may protect the cells from oxidative stress. Enhanced lipogene...
Regulation of lipid metabolism in cancer cells. In cancer cells, glucose uptake and glycolysis are markedly up-regulated by RTKs via the PI3K/Akt/mTOR signaling pathway, generating large amounts of pyruvate. Pyruvate is converted to lactate and it also enters the mitochondria, where it forms cit...
Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that occur in lipid metabolism during ferroptosis and have provided intriguing i
Cancer cells are often exposed to a metabolically challenging environment with scarce availability of oxygen and nutrients. This metabolic stress leads to changes in the balance between the endogenous synthesis and exogenous uptake of fatty acids, which
These multiple roles of FAs in membrane structure, energy metabolism, and signaling highlight the importance of processes that control FA levels in cancer cells. This includes the regulation of FA synthesis, modification, and uptake from the microenvironment and their release from other lipid species...
Targeting cell metabolism offers promising opportunities for the development of drugs to treat cancer. We previously found that the fatty acyl-CoA synthetase VL3 (ACSVL3) is elevated in malignant brain tumor tissues and involved in tumorigenesis. This study investigates the role of ACSVL3 in the...
cancer were screened by GEPIA database. Our aim was to screen for differential genes that are closely related to lipid metabolism in colorectal cancer. Three genes,FASN,PTGS1, andSCD, which were more studied among the first 15 most significantly differentiated genes, were excluded, and the ...
Reprogrammed fatty acid metabolism mainly characterized by increased de novo lipgenesis has been increasingly established as a hallmark of cancer. Elevated lipgenesis, including de novo fatty acid synthesis1,2and cholesterol biosynthesis3,4, provides cancer cells with building blocks, signaling molecules ...