Cancer cells employ lipid droplets to ensure energy production and redox balance, modulate autophagy, drive membrane synthesis, and control its composition, thereby minimizing stress and fostering tumor progression. As regulators of (poly)unsaturated fatty acid trafficking, lipid droplets are also emerging...
Based on the increasingly information about the role of lipid droplets in cancer, emerging from several different models, we suggest the association of lipid droplets with some of the currently established Hallmarks of Cancer—biological traits acquired by cells during cancer multistep development, a c...
& Yang, H. Lipid droplet biogenesis and functions in health and disease. Nat. Rev. Endocrinol. 19, 443–459 (2023). Article CAS PubMed Google Scholar Petan, T. Lipid droplets in cancer. Rev. Physiol. Biochem Pharm. 185, 53–86 (2023). Ralhan, I., Chang, C.-L., Lippincott-...
Lipid droplets: could they be involved in cancer growth and cancer-microenvironment communications? lipid droplets(LDs)predominantly in aggressive cancer cells and their microenvironment,such as the cancer cells and microenvironment in Zajdela ascites hepatoma... P Schwartsburd - 癌症通讯(英文) 被引量...
Although they are beneficial to cell physiology under most conditions, lipid droplets might also exacerbate cytotoxicity and disease progression in certain disease settings. Therapies targeting lipid droplet biogenesis, growth and degradation might be promising avenues for treating cancer, viral infection and...
Yi et al. indicated increased de novo lipogenesis and extracellular lipid uptake contribute to the accumulation of lipid droplets in cancer stem cells, which is beneficial for self-renewal growth and tumor initiation [156]. However, whether the increased levels of unsaturated lipids induce LSC stem...
2019, Nature Dynamics and functions of lipid droplets 2019, Nature Reviews Molecular Cell Biology Lipid droplets in cancer: Guardians of fat in a stressful world 2018, Molecules View all citing articles on Scopus 6 Lead Contact © 2017 Elsevier Inc. ...
Local environment of the lipid droplets inside the breast cancer cells, MCF7 and in non-malignant breast cells, MCF10A is monitored using time-resolved confocal microscopy. For this study, a coumarin-based dye C153 has been used. The local polarity and the solvation dynamics indicate that a ...
Fig. 1: Acidosis-adapted cancer cells exhibit accumulation of lipid droplets. aRepresentative electron microscopy pictures depicting lipid droplet (LD) accumulation in acidosis-adapted SiHa and HCT-116 cancer cells. Scale bar: 2 µm.b,cRepresentative pictures of BODIPY 493/503- (b) and ORO-...
MUFAs, intracellular lipolysis and FA oxidation are downregulated under hypoxia, which results in the increased accumulation of TGs in lipid droplets. Increased TG synthesis and decreased lipolysis are both suggested to be strategies adopted by different cancer cells to evade lipotoxicity during hypoxia....