Lipid rafts and Tcell receptor signaling: a critical reevaluation - Pizzo, Giurisato, et al. - 2002Pizzo, P., Giurisato, E., Tassi, M., Benedetti, A., Pozzan, T. & Viola, A. 2002 Lipid rafts and T cell receptor signaling: a critical re-evaluation. Eur. J. Immunol. 32, 3082-...
A current theory that describes early signalling events incorporates the function of lipid rafts, microdomains at the plasma membrane with distinct lipid and protein composition. Lipid rafts have been implicated in diverse biological functions in mammalian cells. In T cells, molecules with a key role...
Investigates the role of lipid rafts in T cell antigen receptor (TCR) signaling. Mechanism of activation of tyrosine phosphorylation by TCR; Effect of aggregation of TCR by anti-CD3 mAb crosslinking on raft-associated proteins; Analysis of signaling in mutant Jurkat T cell lines in response to ...
Lipid rafts have been shown to play a role in T cell maturation, activation as well as in the formation of immunological synapses in CD4+ helper and CD8+ cytotoxic T cells. However, the differential expression of lipid raft components between CD4+ and CD8+ T cells is still poorly defined....
(lipid rafts) at the immunological synapse, while also exposing phosphatidylserine (PS) within the synapse, thus creating a negatively charged sink that sequesters and inactivates any residual perforin. The resistance of CTLs to perforin underpins their capacity to kill multiple targets, and enables ...
Lipid rafts are critical to the assembly of the T-cell receptor (TCR) signaling machinery. It is not known whether lipid raft properties differ in CD4+ and CD8+ T cells and whether there are age-related differences that may account in part for immune senescence. Data presented here showed ...
[73]. Also, omega-3 FAs regulate pancreatic β-cell insulin secretion by acting on the function and structure of lipid rafts and indirectly reducing the development of proinflammatory mediators in adipose tissue and increasing adipokine synthesis. Omega 3 FAs inhibit inflammatory cytokines, induce ...
CD4+ T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice (2012) CD4+ T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice. .....
Structure and function of lipid rafts in human activated T cells Lipid rafts, specialized membrane microdomains enriched in sphingolipids and cholesterol, have been shown to function as signaling platforms in T cells. Su... Tani-ichi Shizue,M Koji,K Nami,... - 《International Immunology》 被引...
T cell activation through the T cell receptor (TCR) involves partitioning of receptors into discrete membrane compartments known as lipid rafts, and the formation of an immunological synapse (IS) between the T cell and antigen-presenting cell (APC). Compartmentalization of negative regulators of T ...