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mRNALipid nanoparticles (LNPs) have delivered RNA to hepatocytes in patients after intravenous administration. These clinical data support efforts to design LNPs that transfect cells in the central nervous system (CNS). However, delivery to the CNS has been difficult, in large part because ...
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent and treat various diseases. To function in vivo, mRNA requires safe, effective and stable delivery systems that protect the nucleic acid from degradation and that allow ce
Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosis 原文链接:https://doi.org/10.1073/pnas.2116271119 Significance 目前基于mRNA技术的应用主要局限于肝脏疾病,因为缺乏特异性和高效的肝外的体内mRNA递送系统。在这里,我们开发了一个n系列脂质纳米颗粒...
脂质体(Liposomes)、脂质纳米颗粒 (LNP,Lipid Nanoparticles) 和其他基于脂质的制剂已被临床证明可提高多种活性药物成分 (API,,active pharmaceutical ingredients) 的治疗指数。脂质是一类两亲性(amphipathic)生物分子,当掺入药物产品中时,它们表现出理想的安全性和药代动力学特征。最近,由于将 LNP 纳入基于信使 RNA ...
The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy 原文链接:https://doi.org/10.1021/acs.bioconjchem.0c00366 Abstract: -通过基因沉默、蛋白表达或基因修正,基因疗法在治疗几乎任何疾病方面都具有巨大的潜力。为了有效地将核酸有效载荷传递到目标组织,遗传物质需要与传递平台相结合。脂质纳米颗粒(LNPs...
Messenger RNA (mRNA) sta... J Han,J Lim,CPJ Wang,... - 《Nano Convergence》 被引量: 0发表: 2023年 Lipid nanoparticle-mediated messenger RNA delivery for ex vivo engineering of natural killer cells cancer immunotherapyElectroporationLipid nanoparticlesmRNA deliveryNatural killer cellsPolyplexes2023...
molecules Review Lipid Nanoparticles for mRNA Delivery to Enhance Cancer Immunotherapy Hong-Li Wang 1, Zhi-Gang Wang 2,* and Shu-Lin Liu 1,2,* 1 Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences,...
Efficiently develop the next generation of therapeutics by leaning on ProMab’s expertise in formulation and manufacturing of lipid nanoparticles (LNPs) for gene delivery. Our platform uses a validated mRNA delivery system with proven success in the pharmaceutical industry and is ready to expand the ...
Lipid nanoparticles (LNPs) are effective vehicles to deliver mRNA vaccines and therapeutics. It has been challenging to assess mRNA packaging characteristics in LNPs, including payload distribution and capacity, which are critical to understanding struct