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DIANT® offers innovators and CDMOs turnkey nanoparticle / LNP manufacturing solutions and R&D services that increase speed to market and reduce risk.
脂质纳米颗粒(Lipid Nanoparticle,LNP) 是目前主流的载体递送方式,现阶段主要的mRNA疫苗都使用的是此项技术。LNP是一种多组分系统,通常由可电离脂质 (lonizable lipid) 、辅助脂质(Helper lipid) 、胆固醇 (cholesterol) 和聚乙二醇修饰脂质 (PEG-lipid) 组成,它们分工合作,将mRNA包裹在核中以避免降解,帮助其实现有...
Our end-to-end Genomic Medicine Tool Kit uniquely enables access to ionizable lipid mixes through the lipid nanoparticle portfolio, LNP technologies and proven expertise, to establish robust in-house strategies and infrastructure. This results in a sustainable LNP formulation and manufacturing framework ...
LipoDrive™ Lipid-based Drug Delivery Platform MORE Functional Liposome Development Liposomal Formulation Development Liposome Analysis & Characterization Lipid Nanoparticle (LNP) Development Liposome Manufacturing Custom Lipid Synthesis About Us As a pioneer with more than ten years of experience in liposom...
LIPID NANOPARTICLE (LNP) AND USES THEREOF IN CELL THERAPYThe present disclosure relates to a composition comprising lipid particles conjugated to an antibody binding CD2, CD3, CD5 or CD7, the lipid particles comprising a polynucleotide encoding a CAR binding CD19 or BCMA, a polynucleotide encoding...
A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they have to be stored at (ultra)low temperatures. Understanding the root cause of the instability of these vaccines may help to rationally improve mRNA-LNP product stability and thereby ease the temperature condi...
In addition, the category, size, and surface charge of lipids also affect the behavior of lipid nanoparticles in vivo, so the optimization of lipid nanoparticle formulations for nucleic acid delivery has a long way to go. 4.1. Modification of mRNA In the last decade, new technological ...
Middle: EpCAM-CD3-hFc mRNA-LNP-treated T cells significantly decrease tumor growth. Right: Tumor size and weight are significantly decreased with EpCAM-CD3-hFc mRNA-LNP-treated T cells. See all the data in the paper “mRNA-Lipid Nanoparticle (LNP) Delivery of Humanized EpCAM-CD3 Bispecific ...
The optimized LNPs encapsulating tumor-antigen encoding mRNA showed both prophylactic and therapeutic antitumor effects in mice. Keywords: mRNA; spleen; immune cell; vaccine; lipid nanoparticle 1. Introduction Delivering messenger RNA (mRNA) has gained substantial interest for purposes of vaccination due ...