Lipids and lipid nanoparticle formulations for delivery of nucleic acids. US Patent US10166298B2 (2019). Tanaka, H. et al. Self-degradable lipid-like materials based on “hydrolysis accelerated by the intra-particle enrichment of reactant (HyPER)” for messenger RNA delivery. Adv. Funct. Mater...
Lipid nanoparticle (LNP) technology is critical to the advancement of mRNA vaccines. However, most studies focus on technical aspects and neglect the patent landscape. Moreover, there is a lack of differentiation of LNP technology differences among mRNA, mRNA vaccines, and COVID-19 mRNA vaccines,...
(non-polar) was also evaluated for its effect on nanoparticle size, encapsulation, and transfection of LNPs (200 ng mRNA per well). The color code is indicative of polarity (green), non-polarity (yellow), and structural difference from cholesterol (red). Horizontal dashed red line ...
Lipid nanoparticle–mRNA formulations manufactured by rapid mixing exhibit a stable nanostructure17,130,131, in which mRNA molecules can be encapsulated in the interior core through electrostatic interactions with the lipids17,131. This structural feature protects mRNA molecules from nuclease degradation and...
blockade. Ultimately, the expression of these immunomodulators is associated with better overall survival in patients with cancer. Similar content being viewed by others Intravenous administration of IL-12 encoding self-replicating RNA-lipid nanoparticle complex leads to safe and effective antitumor ...
Placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model Article 04 December 2024 The soluble (pro)renin receptor promotes a preeclampsia-like phenotype both in vitro and in vivo Article Open access 11 April 2024 Data...
S. Nanoparticle PEGylation for imaging and therapy. Nanomedicine 6, 715–728 (2011). Article CAS Google Scholar Akinc, A. et al. The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs. Nat. Nanotechnol. 14, 1084–1087 (2019). Article CAS ...
Inhaled delivery of messenger RNA (mRNA) using lipid nanoparticle (LNP) holds immense promise for treating pulmonary diseases or serving as a mucosal vaccine. However, the unsatisfactory delivery efficacy caused by the disintegration and aggregation of LNP during nebulization represents a major obstacle....
To unlock the full promise of messenger (mRNA) therapies, expanding the toolkit of lipid nanoparticles is paramount. However, a pivotal component of lipid nanoparticle development that remains a bottleneck is identifying new ionizable lipids. Here we describe an accelerated approach to discovering effec...
we develop a lyophilization technique to prepare SARS-CoV-2 mRNA-lipid nanoparticle vaccines with long-term thermostability. The physiochemical properties and bioactivities of lyophilized vaccines showed no change at 25 °C over 6 months, and the lyophilized SARS-CoV-2 mRNA vaccines could elicit po...