It also compiles the patents, case studies of successful topical delivery with these drug carriers and their use in finished marketed products available world-wide.doi:10.1016/B978-0-12-816705-2.00001-1Indu Pal KaurGarima SharmaMandeep SinghMohhammad RamzanJoga SinghSimarjot Kaur SandhuJaspreet Singh GulatiNanomaterials for Clinic...
This study aims to develop ezetimibe-loaded solid lipid nanoparticles (SLNs) and compare them with marketed product and drug suspension for dissolution and bioavailability. Ezetimibe-loaded SLNs were fabricated using high pressure homogeniser (HPH). The content of SLNs were (drug, solid lipid and...
SLN is a carrier that is used to specifically target a particular site. SLNs can be used to deliver neuropharmaceuticals. Solid lipid nanoparticles can be formulated in various forms, such as nanosuspensions, nanocrystals, nanogels, liposomes, niosomes, nanoparticles, and nanostructured lipid carriers...
Bioavailability of Herbal Products 10.5.8 Solid Lipid Nanoparticles and NLCs Solid lipid nanoparticles (SLNs) are prepared from lipids that are solid at room temperature as well as at body temperature. Different solid lipids are exploited to produce SLNs, such as, tripalmitin, cetyl alcohol, cety...
Antibiotics Amphotericin B ~ 8.5 Intravenous Mice 5 mg/kgb Lower toxicity and better therapeutic effect in comparison to marketed products [63] Enrofloxacin ~ 6.1 – ~ 7.4c Intramuscular Kunming species mice 0.45 mgb Increased bioavailability, sustained drug release [30] Antihypertensive drugs Candesarta...
In yet another embodiment, nelfinavir mesylate (marketed under the tradename Viracept by Agouron Pharmaceuticals, Inc. in La Jolla, Calif.) is an HIV protease inhibitor which may be formulated into the dosage form of the invention. The dosage forms of the present invention exhibit a release and...
Patents involving natural fats and oils in SLN and NLC composition are listed, yet it is important to note that the approved marketed formulations are mainly cosmetic, not pharmaceutical, products. Conclusion Natural lipids can enhance topical drug delivery by adding their ability of improving skin ...
blood products and substitutes, cardiac inotropic agents, contrast media, corticosteroids, cough suppressants (expectorants and mucolytics), diagnostic agents, diagnostic imaging agents, diuretics, dopaminergics (antiparkinsonian agents), haemostatics, immuriological agents, lipid regulating agents, muscle ...
In yet another embodiment, nelfmavir mesylate (marketed under the tradename Viracept by Agouron Pharmaceuticals, Inc. in La Jolla, Calif.) is an HIV protease inhibitor which may be formulated into the dosage form of the invention. The dosage forms of the present invention exhibit a release ...
The traditional intravenous administration of AmB in the current marketed formulations results in high drug levels in target organs, but is also associated with significant accumulation in the kidneys, which is highly problematic, as the drug is a known nephrotoxin. In a recent ...