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DIANT® offers innovators and CDMOs turnkey nanoparticle / LNP manufacturing solutions and R&D services that increase speed to market and reduce risk.
in a dose-dependent manner (Fig.2e), confirming that exposure of LNPs to DNA leads not only to particle-surface coating but also to the penetration of DNA into the particle core. The LNP nanostructure maintains an unchanged lamellar d-spacing of approximately 6.98 nm but encompasses...
LNP制备原理 常见LNP制备方法包括乙醇注射法、脂质体挤出法、薄膜水化法、纳米沉淀法、冲击射流式混合法以及微流控混合法等,其中,微流控混合法由于其高包封率,LNP粒径、单分散度(PDI)等核心指标高度可控以及良好的重复性,同时相对简便快速,条件温和,同时容易实现生产放大,已经成为目前临床前研究的首选方法。基本原理:...
Our end-to-end Genomic Medicine Tool Kit uniquely enables access to ionizable lipid mixes through the lipid nanoparticle portfolio, LNP technologies and proven expertise, to establish robust in-house strategies and infrastructure. This results in a sustainable LNP formulation and manufacturing framework ...
This study summarizes the research progress in LNP delivery carrier-assisted targeted controlled release mRNA vaccines in tumor immunity. The role of LNPs in improving mRNA stability, immunogenicity, and targeting is discussed. This review aims to systematically summarize the latest ...
LipoDrive™ Lipid-based Drug Delivery Platform MORE Functional Liposome Development Liposomal Formulation Development Liposome Analysis & Characterization Lipid Nanoparticle (LNP) Development Liposome Manufacturing Custom Lipid Synthesis About Us As a pioneer with more than ten years of experience in liposom...
Currently, the leading mRNA COVID-19 vaccines (Table 1) are all utilizing LNP technology. This illustrates the successes achieved with this type of nanoparticle to stabilize mRNA and successfully deliver it into cells (Pardi et al., 2015). The LNPs in mRNA COVID-19 vaccines consist of four...
Placental nanoparticle-mediated IGF1 gene therapy corrects fetal growth restriction in a guinea pig model Article 04 December 2024 The soluble (pro)renin receptor promotes a preeclampsia-like phenotype both in vitro and in vivo Article Open access 11 April 2024 Data...
In addition, the category, size, and surface charge of lipids also affect the behavior of lipid nanoparticles in vivo, so the optimization of lipid nanoparticle formulations for nucleic acid delivery has a long way to go. 4.1. Modification of mRNA In the last decade, new technological ...