Excess cholesterol is eliminated from the cell through ATP-binding cassette transporter A1 (ABCA1) [35]. In addition, low-density lipoproteins (LDLs) are taken up through membrane receptors (LDLRs), and high LDLRs levels promote LDL cholesterol-mediated breast cancer growth [36]. Reprogramming ...
HMG-CoA reductase is regulated allosterically and by covalent modification. Furthermore, both its synthesis and degradation rates are controlled by a complex of three proteins: Insig, SCAP, and SREBP, which sense cholesterol levels and trigger increased synthesis or degradation of HMG-CoA reductase. ...
et al. Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study. Lipids Health Dis. 9, 62 (2010). Article PubMed PubMed Central Google Scholar Almsherqi, Z. A. Potential role of plasmalogens in the modulation of biomembrane morphology. Front. Cell Dev. ...
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Cholesterol: Factors Determining Blood Cholesterol Levels Z. Rasic-Milutinovic, ... M. Glibetic, in Encyclopedia of Food and Health, 2016 Genetic Factors Serum lipid levels are associated with genetic factors. It has been estimated that genotype participates with around 40–60% in the serum tota...
An artificial lipid membrane refers to a supported membrane model used in single molecule studies to optimize signal-to-background contrast by selecting specific dyes, solvents, and emission filters to enhance detection efficiency and improve contrast. ...
Although we had not initially sought to investigate lipid metabolism, the increase in HILPDA expression, combined with an increase in hallmark adipogenesis genes (p = 2.45 × 10−5, FDR q-value = 1.36 × 10−4) and cholesterol homeostasis genes (p = 2....
High cholesterol is a major risk factor for cardiovascular disease1. Currently, no drug lowers cholesterol through directly promoting cholesterol excretion. Human genetic studies have identified that the loss-of-function Asialoglycoprotein receptor 1 (AS
Meta-analysis reveals up-regulation of cholesterol processes in non-alcoholic and down-regulation in alcoholic fatty liver disease. World J. Hepatol. 9, 443–454 (2017). Article PubMed PubMed Central Google Scholar Legry, V. et al. Bile acid alterations are associated with insulin resistance...
Additionally, inflammation is a common underlying factor in DR, and inflammation generates Cer from SM in the serum membrane. This induces death receptor ligand formation and leads to apoptosis of RPE and photoreceptor cells [29]. In addition to diabetes, circulating Cer was shown to strongly ...