linc-RoRmiR-145Endometrial cancerTumorsphereObjectives. Recently, large intergenic non-coding ribonucleic acids-RoR (linc-RoR) was reported to regulate expression of core stem cell transcription factors (TFs), but its role in endometrial tumorsphere is still unknown. Methods. Fluorescence in situ ...
The long intergenic non-coding RNA, regulator of reprogramming (linc-ROR) is an oncogene and plays a key role in the embryonic stem cell maintenance and is involved in cancer progression. The objective of this study was to analyze linc-ROR expression in pancreatic ductal adenocarcinoma (PDAC) a...
Nanog mRNA表达采用RT-qPCR技术检测诱导生成的OCS-LC中Linc-ROR mRNA较诱导前A2780贴壁细胞的表达差异,si-OCS-LC和control-OCS-LC细胞球中核心转录因子Oct-4、Nanog mRNA表达水平,以及Linc-ROR RNA、miR-181c-5p RNA的变化情况。
The lncRNA linc-ROR has been shown to contribute to the maintenance of induced pluripotent stem cells and embryonic stem cells. In this study, we discovered that linc-ROR was upregulated in breast tumor samples, and ectopic overexpression of linc-ROR in immortalized human mammary epithelial cells...
Highlights ► A lincRNA-RoR function as a key competing endogenous RNA in hESCs ► Linc-RoR prevents core TFs from microRNA-mediated suppression ► Linc-RoR forms a feedback loop with core TFs and microRNAs ► Linc-RoR is a key regulator of hESC self-renewal and differentiationPrevious...
The inhibition of lincRNA‐ROR (ROR) downregulated HERC5 expression and elevated p53 expression in TGF‐β1‐stimulated LX‐2 cells. Furthermore, the expression of p53 was almost unchanged after TGF‐β1‐stimulated LX‐2 cells were co‐transfected with a ROR‐expressing plasmid ...
LincRNA-ROR在HGSOC中的表达及LincRNA-ROR的表达与HGSOC的关系.结果对总RNA提取后进行RNA质量鉴定,根据组织样本提取出的RNA结果,检测RNA纯度核酸的光度/蛋白吸光度(A260/A280),在1.8~2.0之间认定为合格.在三个不同样本的琼脂糖凝胶电泳图中能够清晰看到3个RNA电泳条带,其中28S/18S条带亮度比为2:1,表明RNA...
长链非编码RNA Linc-ROR与恶性肿瘤发生,发展关系的研究进展刘帅臣李玉明
Endogenous miRNA Sponge LincRNA-ROR promotes proliferation, invasion and stem cell-like phenotype of pancreatic cancer cells. Cell Death Dis. 2017; 3:17004.Fu, Z., Li, G., Li, Z., Wang, Y., Zhao, Y., Zheng, S., Ye, H., Luo, Y., Zhao, X., Wei, L., et al. (2017). ...
Li C, Lu L, Feng B, et al.The lincRNA-ROR/miR-145 axis promotes inva- sion and metastasis in hepatocellular carcinoma via induction of epithelial- mesenchymal transition by targeting ZEB2. Sci Rep. 2017;7(1):4637.Li C,Lu L,Feng B,et al.The lincRNA-ROR/miR-145 axis promotes ...