基因简介 中英文全称:LIM 域和肌动蛋白结合1 LIM domain and actin binding 1 分布:肌动蛋白细胞骨架 活性:锌离子结合|金 属离子结合 OMIM/位置:608364 12q13 ...
华人学者研究成果:抑制LIMA1可治疗高胆固醇血症 美国东部时间2018年6月7日,由武汉大学宋保亮教授和新疆医科大学第一附属医院马依彤教授作为共同通讯作者,《科学》杂志发表了一项最新成果,表明抑制LIMA1(LIM domain and actin binding 1;SREBP3 )能降低胆固醇吸收,有助于治疗高胆固醇血症。 低密度脂蛋白胆固醇( LDL -...
肿瘤上皮蛋白丢失(Epithelial protein lost in neoplasm,EPLIN)又名LIM结构域和肌动蛋白结合蛋白1(LIM domain and actin binding 1,LIMA1),它是一种肌动蛋白相关分子,与乳腺癌、前列腺癌、食道癌、肺癌等各种癌症的发展和进展有关。顾名思义,随着癌症的进展,EPLIN的表达经常会丢失。EPLIN在肌动蛋白动力学的调节...
基因描述 Homo sapiens LIM domain and actin binding 1 (LIMA1), transcript variant 1, mRNA DNA编码区: atggaatcatctccatttaatagacggcaatggacctcactatcattgagggtaacagcc aaagaactttctcttgtcaacaagaacaagtcatcggctattgtggaaatattctccaag taccagaaagcagctgaagaaacaaacatggagaagaagagaagtaacaccgaaaatctc tcccagcact...
LIMA1 is a LIM domain and Actin binding 1 protein that acts as a skeleton protein to promote cholesterol absorption, which makes it an ideal target for interfering with lipid metabolism. However, the detailed regulation of LIMA1 remains unclear. Here, we identified that ring finger protein 40 ...
Actin binding LIM 1 (abLIM1) is a cytoskeletal actin‐binding protein that has been implicated in interactions between actin filaments and cytoplasmic targets. Previous biochemical and cytochemical studies have shown that abLIM1 interacts and co‐localizes with F‐actin in the retina and muscle. ...
LMCD1, a member of the LIM protein family, contains a novel cysteine-rich domain at the N terminus, a central PET (Prickle, Espinas, and Testin) domain, and two LIM domains at the C-terminal region (9). The proteins containing LIM domains are known to have distinct functions in gene ...
Moreover, bimolecular fluorescence complementation unveils the spatial orientation of the paxillin LIM-array, juxtaposing the positive LIM4 to the plasma membrane and the β3 integrin-tail, while in vitro binding assays point to LIM1 and/or LIM2 interaction with talin-head domain. These data ...
The LIM domain of Lhx3 can bind to both NLI and Isl1. In V2a interneurons in which Lhx3 is expressed without Isl1, Lhx3 binds to NLI, which dimerizes to form a tetrameric 2-Lhx3:2-NLI complex for DNA binding. In v-MN motor neurons, Isl1 displaces Lhx3 from NLI, thereby ...
Gene SummaryThis gene encodes a member of the actin-binding LIM (abLIM) family of proteins. These proteins are characterized by an N-terminal LIM domain and a C-terminal dematin-like domain. The encoded protein interacts with actin filaments and may be a component of adherens junctions in se...