Finally, the assembly of actin by nucleators such as Arp2/3 or formins requires a local pool of available G-actin (Fig. 2). Profilin is a G-actin-binding protein that facilitates nucleotide exchange (ADP to ATP), a switch that allows actin to polymerize more readily at the barbed end...
基因/抗原:ACTA2 别名:Actin, aortic smooth muscle, Alpha-actin-2, Cell growth-inhibiting gene 46 protein, ACTA2, ACTSA, ACTVS, GIG46 货号:FS-C6449 实验类型:夹心法 应用范围:血清、血浆、组织匀浆、细胞培养物上清或其它相关液体(本产品仅供实验室科研及非临床用途) ...
Moreover, many studies have demonstrated that other actin-binding proteins, such as actin-interacting protein 1 (AIP1), cyclase associated protein (CAP), coronin, tropomyosins (TPM), cortactin and actin-related proteins-2/3 (Arp2/3), can potently modulate ADF/cofilin’s ability to act on ...
The dynamics of the actin cytoskeleton is regulated by the actin depolymerizing protein, Cofilin. Kinases, such as LIMK1/2 and TESK1/2, regulate Cofilin activity through phosphorylation, which prevents its binding to actin [23], [24], [25], [26], [27]. However, functionally active Cofilin...
The acquisition of self-sufficiency in growth properties is unlikely to result from increased activity of the mediators of Hippo signalling, Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), as we could not observe YAP/TAZ being enriched in the nuclei of...
(2004). FHL5, a novel actin-binding protein, is highly expressed in eel gill pillar cells and responds to wall tension. Am. J. Physiol.Regul. Integr. Comp. Physiol. 287, R1141-R1154.Mistry AC, Kato A, Tran YH, Honda S, Tsukada T, Takei Y, Hirose S. FHL5, a novel actin-...
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司生产的Pyrabactin,最新报价:1901.12元/MG,产品编号B3438品牌Sigma颜色whitetooff-white测定≥98%(HPLC)形式powder溶解性DMSO:>10mg/mL分子量377.26储
Recently, several GTP-Rho binding proteins were isolated. Among them, p140mDia and p160ROCK appear to work as Rho effectors mediating its action on the cytoskeleton. p140mDia induces actin polymerization by recruiting an actin binding protein, profilin, to the site of Rho action. p160ROCK ...
EHBP1 is an adaptor protein that regulates vesicular trafficking by recruiting Rab8 family members and Eps15-homology domain-containing proteins 1/2 (EHD1/2). It also links endosomes to the actin cytoskeleton. However, the underlying molecular mechanism of activation of EHBP1 actin-binding activity...
Previous work has shown that inhibition of VDAC channel opening using 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) counteracts the p57KIP2-death promoting effect.14Therefore, the effect of p57KIP2on the mitochondrial protein levels of HK-1, an important regulator of VDAC channel...