The acquisition of self-sufficiency in growth properties is unlikely to result from increased activity of the mediators of Hippo signalling, Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), as we could not observe YAP/TAZ being enriched in the nuclei of...
别名:Actin, aortic smooth muscle, Alpha-actin-2, Cell growth-inhibiting gene 46 protein, ACTA2, ACTSA, ACTVS, GIG46 货号:FS-C6449 实验类型:夹心法 应用范围:血清、血浆、组织匀浆、细胞培养物上清或其它相关液体(本产品仅供实验室科研及非临床用途) ...
ARHGDIBandRRAS. MiR-449-mediated silencing of eitherARHGAP1,ARHGDIBorRRASwas respectively abolished when miR-34/449-predicted binding sites were mutated (Fig. 4c). Among the four miR-449-binding sites in the 3′-UTR ofRRAS, the strongest effect was observed for the most 3′-site, which ...
3). Afadin is an actin-binding protein that colocalizes in synapses with the GEF kalirin-7 (50, 51) and is critical for dendritic spine structure and function (52). Protocadherins Perhaps the most compelling link between cadherins and brain disorders, however, are the protocadherins (Fig. ...
The dynamics of the actin cytoskeleton is regulated by the actin depolymerizing protein, Cofilin. Kinases, such as LIMK1/2 and TESK1/2, regulate Cofilin activity through phosphorylation, which prevents its binding to actin [23], [24], [25], [26], [27]. However, functionally active Cofilin...
The ParM protein, encoded by the parMRC locus from plasmid R1, is the best-characterized actin homolog present in prokaryotes. In conjunction with a nucleoprotein complex formed by a DNA binding protein ParR and a DNA centromere parC, ParM constructs a simple mitotic spindle that pushes plasmid ...
Pyrabactin has been used to form a homogeneous complex of PYL3−pyrabactin for the protein purification by size-exclusion chromatography. 生化/生理作用 Pyrabactin is a synthetic plant growth inhibitor that acts as a seed-selective abscisic acid (ABA) agonist. Pyrabactin acts through Pyrabacti...
RHO-family GTPases act as molecular switches to modulate actin organization and dynamics. In response to a signal, RHO turns on an effector protein that directly regulates the activity of actin-binding proteins. Different RHO members function to control distinct forms of F-actin. Plants possess ...
glycerol 3 phosphate dehydrogenase GFP: green fluorescent protein HK-1: hexokinase-1 Jasp: jasplakinolide LIMK-1: LIM domain kinase-1 p21/Cip1/CDKN1A: cyclin-dependent kinase inhibitor 1A p27/Kip1/CDKN1B: cyclin-dependent kinase inhibitor 1B ...
EHBP1 is an adaptor protein that regulates vesicular trafficking by recruiting Rab8 family members and Eps15-homology domain-containing proteins 1/2 (EHD1/2). It also links endosomes to the actin cytoskeleton. However, the underlying molecular mechanism