Ligand-receptor pair, binding energy, co-evolution, chemokine receptorsUnderstanding the interactions between protein receptor-ligand pairs is of great pharmaceutical interest for structure-based drug design. It has become apparent that identifying interesting ligand-receptor pairs by computational techniques...
Rheological analysis of the adhesive interactions of red blood cells parasitized by Plasmodium falciparum. ratio of affinity to fracture energy is different for different receptor/ligand pairs, with ICAM-1 appearing to be the more efficient immobilizing receptor... GB Nash,BM Cooke,K Marsh,... -...
(namely to remove its hypergraph aspect), we extracted the pair of cells that expressed the highest level of ligand and the highest level of receptor; we refer to these as the major-transmitter and major-receiver, respectively, and to the pair as the major-signalling pair (Supplementary Data...
摘要: PROBLEM TO BE SOLVED: To provide a ligand-receptor interaction detecting method capable of reducing troublesome complication in preparation of a biomolecule array, and capable of measuring a ligand-receptor interaction without requiring masking....
Real-Time Analysis of Ligand–Receptor Dynamics and Binding Pocket Structure of the Formyl Peptide Receptor Larry A.Sklar, inCellular and Molecular Mechanisms of Inflammation: Signal Transduction in Inflammatory Cells, Part A, 1992 Publisher Summary ...
Beyond pathway-level comparison, SpatialDM allows differential analysis on a certain ligand-receptor pair (Supplementary Dataset 8). While traditional pathway enrichment may have ignored BMP pathway enrichment in adults, SpatialDM refines the adult-specific interactions to BMP2 and its receptors (BMPR1A...
1) expensive labelling of the macromolecule is not required, as only the ligand signals are detected; 2) no limitations about the upper size of the protein, using a high-molecular-weight receptor results, indeed, in readily detectable ligand signals; 3) small amount of receptor necessary (typic...
[Plant Signaling & Behavior 3:12, 1109-1110; December 2008]; ©2008 Landes Bioscience Article Addendum Identification of a putative receptor-ligand pair controlling cell separation in plants Grethe-Elisabeth Stenvik, Melinka A. Butenko and Reidunn B. Aalen* Department of Molecular Biosciences;...
287 ligand–receptor signalling paths between all cell types, we found that at a threshold of 10 TPM for both interacting partners all 144 cell types had the potential to signal to each other through a minimum of 22 signalling paths and that on average a pair of cells can communicate using...
We begin with the analysis of single receptor–ligand bonds because these measurements provide a yardstick to measure the forces applied relative to the expected bond strength. To measure single receptor–ligand bonds it is necessary to isolate the single interaction and to develop tools that are ...