In addition, we discuss the use of fluorescence spectroscopy for detecting and characterizing conformational changes in receptors induced by the binding of ligands. Such studies have provided strong evidence for diversity of receptor conformations elicited by different ligands, consistent with the idea ...
Their results demonstrated that generative models can leverage pharmacophoric information to produce molecules with distinct structures that maintain crucial non-bond interactions with receptors. Similarly, LigDream encodes and decodes 3D voxels representing five common types of pharmacophore features for de...
Their results demonstrated that generative models can leverage pharmacophoric information to produce molecules with distinct structures that maintain crucial non-bond interactions with receptors. Similarly, LigDream encodes and decodes 3D voxels representing five common types of pharmacophore features for de...
For various ligands, illustrative receptors forming the other half of a ligand-receptor pair include antibodies, enzymes, lectins, Fab fragments, and the like. Commonly, the receptor will be an antibody and the analyte or analyte derivative will act as an antigen or hapten. As used herein, "...
Cellular responses depend on the interactions of extracellular ligands, such as nutrients, growth factors, or drugs, with specific cell-surface receptors. The sensitivity of these interactions to non-physiological conditions, however, makes them challenging to study using in vitro assays. Here we prese...
http://genomebiology.com/2005/6/6/223 Table 1 Structures, expression patterns and receptors of B7 ligands Ligand name (alternative names) Structure Protein expression pattern in lymphoid cells* mRNA expression in non-lymphoid tissues or cells Receptor Function of ligand-receptor interaction B7.1 (...
The targets of thyroid hormones are the thyroid receptors (TRs), which belong to the nuclear receptor (NR) superfamily. Two major classes of TR receptors are known, TRα and TRβ, each of which is expressed in multiple isoforms (TRα-1, TRα-2, TRβ-1, TRβ-2). The thyroid ...
b) Cartoon diagram for the definition of the cooperativity in a multivalent system. The unitless parameter α accounts for the cooperativity of the binding during aggregation. If α < 1, the system is negatively cooperative and a complex of two bivalent receptors and one bivalent ligand, (R...
In preferred forms the ligand binds to TNF in a manner such that the induction of endothelial procoagulant activity of the TNF is inhibited; the binding of TNF to receptors on endothelial cells is inhibited; the induction of fibrin deposition in the tumour and tumour regression activities of the...
Target molecules include natural and synthetic polymers, including proteins, polysaccharides, glycoproteins, hormones, receptors and cell surfaces, and small molecules such as drugs, metabolites, cofactors, transition state analogs and toxins. BACKGROUND OF THE INVENTION Most proteins or small molecules...